Molecular basis for assembly of the shieldin complex and its implications for NHEJ

Shieldin, including SHLD1, SHLD2, SHLD3 and REV7, functions as a bridge linking 53BP1-RIF1 and single-strand DNA to suppress the DNA termini nucleolytic resection during non-homologous end joining (NHEJ). However, the mechanism of shieldin assembly remains unclear. Here we present the crystal struct...

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Detalles Bibliográficos
Autores principales: Liang, Ling, Feng, Jiawen, Zuo, Peng, Yang, Juan, Lu, Yishuo, Yin, Yuxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181697/
https://www.ncbi.nlm.nih.gov/pubmed/32332881
http://dx.doi.org/10.1038/s41467-020-15879-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181697/
https://www.ncbi.nlm.nih.gov/pubmed/32332881
http://dx.doi.org/10.1038/s41467-020-15879-5

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