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ERK1/2-Nanog signaling pathway enhances CD44(+) cancer stem-like cell phenotypes and epithelial-to-mesenchymal transition in head and neck squamous cell carcinomas
Head and neck squamous cell carcinomas (HNSCCs) harbor a subset of cells that are CD44(+) and present with malignancy and radiotherapy resistance. As a key regulator of self-renewal, Nanog expression not only determines cell fate in pluripotent cells but also mediates tumorigenesis in cancer cells;...
Autores principales: | Huang, Chuang, Yoon, Changhwan, Zhou, Xiao-Hong, Zhou, Ying-Chun, Zhou, Wen-Wen, Liu, Hong, Yang, Xin, Lu, Jun, Lee, Sei Young, Huang, Kun |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181750/ https://www.ncbi.nlm.nih.gov/pubmed/32327629 http://dx.doi.org/10.1038/s41419-020-2448-6 |
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