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Ptch2/Gas1 and Ptch1/Boc differentially regulate Hedgehog signalling in murine primordial germ cell migration

Gas1 and Boc/Cdon act as co-receptors in the vertebrate Hedgehog signalling pathway, but the nature of their interaction with the primary Ptch1/2 receptors remains unclear. Here we demonstrate, using primordial germ cell migration in mouse as a developmental model, that specific hetero-complexes of...

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Detalles Bibliográficos
Autores principales:	Kim, Yeonjoo, Lee, Jiyoung, Seppala, Maisa, Cobourne, Martyn T., Kim, Soo-Hyun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181751/ https://www.ncbi.nlm.nih.gov/pubmed/32332736 http://dx.doi.org/10.1038/s41467-020-15897-3

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