Photomutagenicity of chlorpromazine and its N-demethylated metabolites assessed by NGS

The human genome is constantly attacked by endogenous and exogenous agents (ultraviolet light, xenobiotics, reactive oxygen species), which can induce chemical transformations leading to DNA lesions. To combat DNA damage, cells have developed several repair mechanisms; however, if the repair is defe...

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Detalles Bibliográficos
Autores principales: Agúndez, José A. G., García-Martín, Elena, García-Lainez, Guillermo, Miranda, Miguel A., Andreu, Inmaculada
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181754/
https://www.ncbi.nlm.nih.gov/pubmed/32327675
http://dx.doi.org/10.1038/s41598-020-63651-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181754/
https://www.ncbi.nlm.nih.gov/pubmed/32327675
http://dx.doi.org/10.1038/s41598-020-63651-y

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