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Photomutagenicity of chlorpromazine and its N-demethylated metabolites assessed by NGS
The human genome is constantly attacked by endogenous and exogenous agents (ultraviolet light, xenobiotics, reactive oxygen species), which can induce chemical transformations leading to DNA lesions. To combat DNA damage, cells have developed several repair mechanisms; however, if the repair is defe...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181754/ https://www.ncbi.nlm.nih.gov/pubmed/32327675 http://dx.doi.org/10.1038/s41598-020-63651-y |