Chemotherapy-induced pyroptosis is mediated by BAK/BAX-caspase-3-GSDME pathway and inhibited by 2-bromopalmitate

Many chemotherapy treatments induce apoptosis or pyroptosis through BAK/BAX-dependent mitochondrial pathway. BAK/BAX activation causes the mitochondrial outer membrane permeabilization (MOMP), which induces the activation of pro-apoptotic caspase cascade. GSDME cleavage by the pro-apoptotic caspases...

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Detalles Bibliográficos
Autores principales: Hu, Lei, Chen, Meng, Chen, Xueran, Zhao, Chenggang, Fang, Zhiyou, Wang, Hongzhi, Dai, Haiming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181755/
https://www.ncbi.nlm.nih.gov/pubmed/32332857
http://dx.doi.org/10.1038/s41419-020-2476-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181755/
https://www.ncbi.nlm.nih.gov/pubmed/32332857
http://dx.doi.org/10.1038/s41419-020-2476-2

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