Intra-striatal AAV2.retro administration leads to extensive retrograde transport in the rhesus macaque brain: implications for disease modeling and therapeutic development

Recently, AAV2.retro, a new capsid variant capable of efficient retrograde transport in brain, was generated in mice using a directed evolution approach. However, it remains unclear to what degree transport will be recapitulated in the substantially larger and more complex nonhuman primate (NHP) bra...

Descripción completa

Detalles Bibliográficos
Autores principales: Weiss, Alison R., Liguore, William A., Domire, Jacqueline S., Button, Dana, McBride, Jodi L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181773/
https://www.ncbi.nlm.nih.gov/pubmed/32332773
http://dx.doi.org/10.1038/s41598-020-63559-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181773/
https://www.ncbi.nlm.nih.gov/pubmed/32332773
http://dx.doi.org/10.1038/s41598-020-63559-7

Ejemplares similares