Intra-striatal AAV2.retro administration leads to extensive retrograde transport in the rhesus macaque brain: implications for disease modeling and therapeutic development

Recently, AAV2.retro, a new capsid variant capable of efficient retrograde transport in brain, was generated in mice using a directed evolution approach. However, it remains unclear to what degree transport will be recapitulated in the substantially larger and more complex nonhuman primate (NHP) bra...

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Detalles Bibliográficos
Autores principales: Weiss, Alison R., Liguore, William A., Domire, Jacqueline S., Button, Dana, McBride, Jodi L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181773/
https://www.ncbi.nlm.nih.gov/pubmed/32332773
http://dx.doi.org/10.1038/s41598-020-63559-7

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