Robust autoactivation for apoptosis by BAK but not BAX highlights BAK as an important therapeutic target

BAK and BAX, which drive commitment to apoptosis, are activated principally by certain BH3-only proteins that bind them and trigger major rearrangements. One crucial conformation change is exposure of their BH3 domain which allows BAK or BAX to form homodimers, and potentially to autoactivate other...

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Detalles Bibliográficos
Autores principales: Iyer, Sweta, Uren, Rachel T., Dengler, Michael A., Shi, Melissa X., Uno, Etsuko, Adams, Jerry M., Dewson, Grant, Kluck, Ruth M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181796/
https://www.ncbi.nlm.nih.gov/pubmed/32327636
http://dx.doi.org/10.1038/s41419-020-2463-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181796/
https://www.ncbi.nlm.nih.gov/pubmed/32327636
http://dx.doi.org/10.1038/s41419-020-2463-7

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