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Robust autoactivation for apoptosis by BAK but not BAX highlights BAK as an important therapeutic target
BAK and BAX, which drive commitment to apoptosis, are activated principally by certain BH3-only proteins that bind them and trigger major rearrangements. One crucial conformation change is exposure of their BH3 domain which allows BAK or BAX to form homodimers, and potentially to autoactivate other...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181796/ https://www.ncbi.nlm.nih.gov/pubmed/32327636 http://dx.doi.org/10.1038/s41419-020-2463-7 |