Chemical modifications of adenine base editor mRNA and guide RNA expand its application scope

CRISPR-Cas9-associated base editing is a promising tool to correct pathogenic single nucleotide mutations in research or therapeutic settings. Efficient base editing requires cellular exposure to levels of base editors that can be difficult to attain in hard-to-transfect cells or in vivo. Here we en...

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Detalles Bibliográficos
Autores principales: Jiang, Tingting, Henderson, Jordana M., Coote, Kevin, Cheng, Yi, Valley, Hillary C., Zhang, Xiao-Ou, Wang, Qin, Rhym, Luke H., Cao, Yueying, Newby, Gregory A., Bihler, Hermann, Mense, Martin, Weng, Zhiping, Anderson, Daniel G., McCaffrey, Anton P., Liu, David R., Xue, Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181807/
https://www.ncbi.nlm.nih.gov/pubmed/32332735
http://dx.doi.org/10.1038/s41467-020-15892-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181807/
https://www.ncbi.nlm.nih.gov/pubmed/32332735
http://dx.doi.org/10.1038/s41467-020-15892-8

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