A masked initiation region in retinoblastoma protein regulates its proteasomal degradation

Retinoblastoma protein (Rb) is a tumor suppressor that binds and represses E2F transcription factors. In cervical cancer cells, human papilloma virus (HPV) protein E7 binds to Rb, releasing it from E2F to promote cell cycle progression, and inducing ubiquitination of Rb. E7-mediated proteasomal degr...

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Detalles Bibliográficos
Autores principales: Tomita, Takuya, Huibregtse, Jon M., Matouschek, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181824/
https://www.ncbi.nlm.nih.gov/pubmed/32332747
http://dx.doi.org/10.1038/s41467-020-16003-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181824/
https://www.ncbi.nlm.nih.gov/pubmed/32332747
http://dx.doi.org/10.1038/s41467-020-16003-3

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