Genetic trajectory and immune microenvironment of lung-specific oligometastatic colorectal cancer

Genetics and immunologic dynamics pushing the evolution of colorectal cancer (CRC) from the primary tumor to the metastases are largely unknown; cancer heterogeneity makes challenging both therapy and mechanistic studies. We selected patients developing CRC with lung-limited metastatic disease as on...

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Detalles Bibliográficos
Autores principales: Ottaiano, Alessandro, Circelli, Luisa, Lombardi, Angela, Scala, Stefania, Martucci, Nicola, Galon, Jerome, Buonanno, Manuela, Scognamiglio, Giosuè, Botti, Gerardo, Hermitte, Fabienne, Savarese, Giovanni, D’Amore, Luigi, Tatangelo, Fabiana, Di Mauro, Annabella, Liguori, Giuseppina, Trotta, Anna Maria, Napolitano, Maria, Capozzi, Monica, Tafuto, Salvatore, Perri, Francesco, La Rocca, Antonello, Caraglia, Michele, Nasti, Guglielmo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181838/
https://www.ncbi.nlm.nih.gov/pubmed/32332709
http://dx.doi.org/10.1038/s41419-020-2480-6
Descripción
Sumario:Genetics and immunologic dynamics pushing the evolution of colorectal cancer (CRC) from the primary tumor to the metastases are largely unknown; cancer heterogeneity makes challenging both therapy and mechanistic studies. We selected patients developing CRC with lung-limited metastatic disease as only illness during their life in order to find any relevant genotype–phenotype relationship. Analysis of 523 cancer-relevant genes and of immune cells infiltration in primary and metastatic tissues revealed atypical genomic trajectories (TMB decrease, KRAS and SMAD4 regressive mutations), specific genetic events (ERBB2 point mutations) and scarce T-cell infiltration. These insights provide novel information in oligometastatic CRC biology and new perspectives for cancer monitoring and anti-cancer therapeutic strategies.

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