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Genetic trajectory and immune microenvironment of lung-specific oligometastatic colorectal cancer
Genetics and immunologic dynamics pushing the evolution of colorectal cancer (CRC) from the primary tumor to the metastases are largely unknown; cancer heterogeneity makes challenging both therapy and mechanistic studies. We selected patients developing CRC with lung-limited metastatic disease as on...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181838/ https://www.ncbi.nlm.nih.gov/pubmed/32332709 http://dx.doi.org/10.1038/s41419-020-2480-6 |
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| author | Ottaiano, Alessandro Circelli, Luisa Lombardi, Angela Scala, Stefania Martucci, Nicola Galon, Jerome Buonanno, Manuela Scognamiglio, Giosuè Botti, Gerardo Hermitte, Fabienne Savarese, Giovanni D’Amore, Luigi Tatangelo, Fabiana Di Mauro, Annabella Liguori, Giuseppina Trotta, Anna Maria Napolitano, Maria Capozzi, Monica Tafuto, Salvatore Perri, Francesco La Rocca, Antonello Caraglia, Michele Nasti, Guglielmo |
| author_facet | Ottaiano, Alessandro Circelli, Luisa Lombardi, Angela Scala, Stefania Martucci, Nicola Galon, Jerome Buonanno, Manuela Scognamiglio, Giosuè Botti, Gerardo Hermitte, Fabienne Savarese, Giovanni D’Amore, Luigi Tatangelo, Fabiana Di Mauro, Annabella Liguori, Giuseppina Trotta, Anna Maria Napolitano, Maria Capozzi, Monica Tafuto, Salvatore Perri, Francesco La Rocca, Antonello Caraglia, Michele Nasti, Guglielmo |
| author_sort | Ottaiano, Alessandro |
| collection | PubMed |
| description | Genetics and immunologic dynamics pushing the evolution of colorectal cancer (CRC) from the primary tumor to the metastases are largely unknown; cancer heterogeneity makes challenging both therapy and mechanistic studies. We selected patients developing CRC with lung-limited metastatic disease as only illness during their life in order to find any relevant genotype–phenotype relationship. Analysis of 523 cancer-relevant genes and of immune cells infiltration in primary and metastatic tissues revealed atypical genomic trajectories (TMB decrease, KRAS and SMAD4 regressive mutations), specific genetic events (ERBB2 point mutations) and scarce T-cell infiltration. These insights provide novel information in oligometastatic CRC biology and new perspectives for cancer monitoring and anti-cancer therapeutic strategies. |
| format | Online Article Text |
| id | pubmed-7181838 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-71818382020-04-29 Genetic trajectory and immune microenvironment of lung-specific oligometastatic colorectal cancer Ottaiano, Alessandro Circelli, Luisa Lombardi, Angela Scala, Stefania Martucci, Nicola Galon, Jerome Buonanno, Manuela Scognamiglio, Giosuè Botti, Gerardo Hermitte, Fabienne Savarese, Giovanni D’Amore, Luigi Tatangelo, Fabiana Di Mauro, Annabella Liguori, Giuseppina Trotta, Anna Maria Napolitano, Maria Capozzi, Monica Tafuto, Salvatore Perri, Francesco La Rocca, Antonello Caraglia, Michele Nasti, Guglielmo Cell Death Dis Article Genetics and immunologic dynamics pushing the evolution of colorectal cancer (CRC) from the primary tumor to the metastases are largely unknown; cancer heterogeneity makes challenging both therapy and mechanistic studies. We selected patients developing CRC with lung-limited metastatic disease as only illness during their life in order to find any relevant genotype–phenotype relationship. Analysis of 523 cancer-relevant genes and of immune cells infiltration in primary and metastatic tissues revealed atypical genomic trajectories (TMB decrease, KRAS and SMAD4 regressive mutations), specific genetic events (ERBB2 point mutations) and scarce T-cell infiltration. These insights provide novel information in oligometastatic CRC biology and new perspectives for cancer monitoring and anti-cancer therapeutic strategies. Nature Publishing Group UK 2020-04-24 /pmc/articles/PMC7181838/ /pubmed/32332709 http://dx.doi.org/10.1038/s41419-020-2480-6 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| spellingShingle | Article Ottaiano, Alessandro Circelli, Luisa Lombardi, Angela Scala, Stefania Martucci, Nicola Galon, Jerome Buonanno, Manuela Scognamiglio, Giosuè Botti, Gerardo Hermitte, Fabienne Savarese, Giovanni D’Amore, Luigi Tatangelo, Fabiana Di Mauro, Annabella Liguori, Giuseppina Trotta, Anna Maria Napolitano, Maria Capozzi, Monica Tafuto, Salvatore Perri, Francesco La Rocca, Antonello Caraglia, Michele Nasti, Guglielmo Genetic trajectory and immune microenvironment of lung-specific oligometastatic colorectal cancer |
| title | Genetic trajectory and immune microenvironment of lung-specific oligometastatic colorectal cancer |
| title_full | Genetic trajectory and immune microenvironment of lung-specific oligometastatic colorectal cancer |
| title_fullStr | Genetic trajectory and immune microenvironment of lung-specific oligometastatic colorectal cancer |
| title_full_unstemmed | Genetic trajectory and immune microenvironment of lung-specific oligometastatic colorectal cancer |
| title_short | Genetic trajectory and immune microenvironment of lung-specific oligometastatic colorectal cancer |
| title_sort | genetic trajectory and immune microenvironment of lung-specific oligometastatic colorectal cancer |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181838/ https://www.ncbi.nlm.nih.gov/pubmed/32332709 http://dx.doi.org/10.1038/s41419-020-2480-6 |
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