The NALCN channel complex is voltage sensitive and directly modulated by extracellular calcium

The sodium leak channel (NALCN) is essential for survival in mammals: NALCN mutations are life-threatening in humans and knockout is lethal in mice. However, the basic functional and pharmacological properties of NALCN have remained elusive. Here, we found that robust function of NALCN in heterologo...

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Detalles Bibliográficos
Autores principales: Chua, H. C., Wulf, M., Weidling, C., Rasmussen, L. P., Pless, S. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7182417/
https://www.ncbi.nlm.nih.gov/pubmed/32494638
http://dx.doi.org/10.1126/sciadv.aaz3154

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7182417/
https://www.ncbi.nlm.nih.gov/pubmed/32494638
http://dx.doi.org/10.1126/sciadv.aaz3154

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