Spiroindolone analogues bearing benzofuran moiety as a selective cyclooxygenase COX-1 with TNF-α and IL-6 inhibitors

To design and discover a new compound can used as a COX with TNF-α and IL-6 inhibitors is highly challenge. A series of spiroindolone-bearing benzofuran moieties were resynthesized from the chalcone-based benzo[b]furan with substituted isatin, and amino acids. The requisite spiroindolone analogues w...

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Detalles Bibliográficos
Autores principales: Altowyan, Mezna Saleh, Barakat, Assem, Al-Majid, Abdullah Mohammed, Al-Ghulikah, H.A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7182988/
https://www.ncbi.nlm.nih.gov/pubmed/32346326
http://dx.doi.org/10.1016/j.sjbs.2020.02.010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7182988/
https://www.ncbi.nlm.nih.gov/pubmed/32346326
http://dx.doi.org/10.1016/j.sjbs.2020.02.010

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