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Discovery of novel L-type voltage-gated calcium channel blockers and application for the prevention of inflammation and angiogenesis

BACKGROUND: The ways in which microglia activate and promote neovascularization (NV) are not fully understood. Recent in vivo evidence supports the theory that calcium is required for the transition of microglia from a surveillance state to an active one. The objectives of this study were to discove...

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Detalles Bibliográficos
Autores principales: Saddala, Madhu Sudhana, Lennikov, Anton, Mukwaya, Anthony, Yang, Yan, Hill, Michael A., Lagali, Neil, Huang, Hu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183139/
https://www.ncbi.nlm.nih.gov/pubmed/32334630
http://dx.doi.org/10.1186/s12974-020-01801-9