A common polymorphism in the mechanosensitive ion channel PIEZO1 is associated with protection from severe malaria in humans

Malaria caused by the apicomplexan parasite Plasmodium falciparum has served as a strong evolutionary force throughout human history, selecting for red blood cell polymorphisms that confer innate protection against severe disease. Recently, gain-of-function mutations in the mechanosensitive ion chan...

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Detalles Bibliográficos
Autores principales: Nguetse, Christian N., Purington, Natasha, Ebel, Emily R., Shakya, Bikash, Tetard, Marilou, Kremsner, Peter G., Velavan, Thirumalaisamy P., Egan, Elizabeth S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183233/
https://www.ncbi.nlm.nih.gov/pubmed/32265284
http://dx.doi.org/10.1073/pnas.1919843117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183233/
https://www.ncbi.nlm.nih.gov/pubmed/32265284
http://dx.doi.org/10.1073/pnas.1919843117

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