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A common polymorphism in the mechanosensitive ion channel PIEZO1 is associated with protection from severe malaria in humans
Malaria caused by the apicomplexan parasite Plasmodium falciparum has served as a strong evolutionary force throughout human history, selecting for red blood cell polymorphisms that confer innate protection against severe disease. Recently, gain-of-function mutations in the mechanosensitive ion chan...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183233/ https://www.ncbi.nlm.nih.gov/pubmed/32265284 http://dx.doi.org/10.1073/pnas.1919843117 |