The corepressor NCOR1 and OCT4 facilitate early reprogramming by suppressing fibroblast gene expression

Reprogramming somatic cells to induced pluripotent stem cells (iPSC) succeeds only in a small fraction of cells within the population. Reprogramming occurs in distinctive stages, each facing its own bottlenecks. It initiates with overexpression of transcription factors OCT4, SOX2, KLF4 and c-MYC (OS...

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Detalles Bibliográficos
Autores principales: Peñalosa-Ruiz, Georgina, Mulder, Klaas W., Veenstra, Gert Jan C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2020
Materias:
Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183309/
https://www.ncbi.nlm.nih.gov/pubmed/32351783
http://dx.doi.org/10.7717/peerj.8952

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183309/
https://www.ncbi.nlm.nih.gov/pubmed/32351783
http://dx.doi.org/10.7717/peerj.8952

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