Novel Roles of Chloroquine and Hydroxychloroquine in Graves’ Orbitopathy Therapy by Targeting Orbital Fibroblasts

CONTEXT: Graves’ orbitopathy (GO) causes infiltrative exophthalmos by inducing excessive proliferation, adipogenesis, and glycosaminoglycan production in orbital fibroblasts (OFs). Interference with OF autophagy is a potential therapy for proptosis. OBJECTIVES: Here, we aimed to evaluate the effects...

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Detalles Bibliográficos
Autores principales: Guo, Yan, Li, Hai, Chen, Xueying, Yang, Huasheng, Guan, Hongyu, He, Xiaoying, Chen, Yuxin, Pokharel, Sunil, Xiao, Haipeng, Li, Yanbing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Clinical Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183395/
https://www.ncbi.nlm.nih.gov/pubmed/32249902
http://dx.doi.org/10.1210/clinem/dgaa161

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183395/
https://www.ncbi.nlm.nih.gov/pubmed/32249902
http://dx.doi.org/10.1210/clinem/dgaa161

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