Cargando…

Novel Roles of Chloroquine and Hydroxychloroquine in Graves’ Orbitopathy Therapy by Targeting Orbital Fibroblasts

CONTEXT: Graves’ orbitopathy (GO) causes infiltrative exophthalmos by inducing excessive proliferation, adipogenesis, and glycosaminoglycan production in orbital fibroblasts (OFs). Interference with OF autophagy is a potential therapy for proptosis. OBJECTIVES: Here, we aimed to evaluate the effects...

Descripción completa

Detalles Bibliográficos
Autores principales:	Guo, Yan, Li, Hai, Chen, Xueying, Yang, Huasheng, Guan, Hongyu, He, Xiaoying, Chen, Yuxin, Pokharel, Sunil, Xiao, Haipeng, Li, Yanbing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Clinical Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183395/ https://www.ncbi.nlm.nih.gov/pubmed/32249902 http://dx.doi.org/10.1210/clinem/dgaa161

Ejemplares similares

SAT-421 Novel Role of Chloroquine and Hydroxychloroquine in Graves’ Orbitopathy Therapy by Targeting Orbital Fibroblasts
por: Guo, Yan, et al.
Publicado: (2020)

Disulfiram Exerts Antifibrotic and Anti-Inflammatory Therapeutic Effects on Perimysial Orbital Fibroblasts in Graves’ Orbitopathy
por: Wang, Xing, et al.
Publicado: (2022)

Orbital Signaling in Graves’ Orbitopathy
por: Draman, Mohd Shazli, et al.
Publicado: (2021)

Therapeutic Effect of Gypenosides on Antioxidant Stress Injury in Orbital Fibroblasts of Graves' Orbitopathy
por: Ma, Chao, et al.
Publicado: (2022)

Endoscopic orbital decompression for Graves’ orbitopathy
por: Lal, Priti, et al.
Publicado: (2013)

Surgical complications in orbital decompression for Graves' orbitopathy
por: Sellari-Franceschini, S., et al.
Publicado: (2016)

Chemokine Expression during Adipogenesis and Inflammation in Orbital Fibroblasts from Patients with Graves' Orbitopathy
por: Lee, Chae Eun, et al.
Publicado: (2020)

Endoscopic intranasal orbital decompression in the course of Graves’ orbitopathy
por: Krzeski, Antoni, et al.
Publicado: (2013)

MicroRNA-27 inhibits adipogenic differentiation in orbital fibroblasts from patients with Graves’ orbitopathy
por: Jang, Sun Young, et al.
Publicado: (2019)

Therapeutic Effect of Guggulsterone in Primary Cultured Orbital Fibroblasts Obtained From Patients with Graves’ Orbitopathy
por: Kim, Bo Ram, et al.
Publicado: (2020)

Role of Proprotein Convertase Subtilisin/Kexin Type 9 in the Pathogenesis of Graves’ Orbitopathy in Orbital Fibroblasts
por: Lee, Ga Eun, et al.
Publicado: (2021)

Graves' Orbitopathy
por: Hiromatsu, Yuji, et al.
Publicado: (2015)

Reasons for revision surgery after orbital decompression for Graves’ orbitopathy
por: Sellari-Franceschini, Stefano, et al.
Publicado: (2008)

Graded Decompression of Orbital Fat and Wall in Patients with Graves' Orbitopathy
por: Lee, Kyou Ho, et al.
Publicado: (2014)

Distinctive Features of Orbital Adipose Tissue (OAT) in Graves’ Orbitopathy
por: Zhang, Lei, et al.
Publicado: (2020)

Endoscopic Orbital Decompression for Graves’ Orbitopathy – A Vietnam Study
por: Pham, Thi My Hanh, et al.
Publicado: (2021)

Glucocorticoids Directly Affect Hyaluronan Production of Orbital Fibroblasts; A Potential Pleiotropic Effect in Graves’ Orbitopathy
por: Galgoczi, Erika, et al.
Publicado: (2022)

The Potential of Artemisinins as Novel Treatment for Thyroid Eye Disease by Inhibiting Adipogenesis in Orbital Fibroblasts
por: Guo, Yan, et al.
Publicado: (2023)

The Role of the Microbiota in Graves’ Disease and Graves’ Orbitopathy
por: Hou, Jueyu, et al.
Publicado: (2021)

Evaluation of activity of Graves’ orbitopathy with multiparameter orbital magnetic resonance imaging (MRI)
por: Cheng, Jingyi, et al.
Publicado: (2023)

Effects of Orbital Decompression on Lamina Cribrosa Depth in Patients with Graves' Orbitopathy
por: Seo, Yuri, et al.
Publicado: (2019)

Asymmetric Graves’ Orbitopathy
por: Panagiotou, Grigorios, et al.
Publicado: (2020)

Artemisinin and the Derivatives Play Novel Role in Treatment for Graves’ Orbitopathy as Conventional Antimalarials
por: Guo, Yan, et al.
Publicado: (2021)

Efficacy of Subantimicrobial Dose Doxycycline for Moderate-to-Severe and Active Graves' Orbitopathy
por: Lin, Miaoli, et al.
Publicado: (2015)

Quercetin Inhibits IL-1β-Induced Inflammation, Hyaluronan Production and Adipogenesis in Orbital Fibroblasts from Graves' Orbitopathy
por: Yoon, Jin Sook, et al.
Publicado: (2011)

Therapeutic effect of ibrutinib, a selective Bruton’s tyrosine kinase inhibitor, in orbital fibroblasts from patients with Graves’ orbitopathy
por: Park, Hyun Young, et al.
Publicado: (2022)

Proposing a surgical algorithm for graduated orbital decompression in patients with Graves’ orbitopathy
por: Stähr, Kerstin, et al.
Publicado: (2021)

Antioxidant Therapy in Graves’ Orbitopathy
por: Lanzolla, Giulia, et al.
Publicado: (2020)

Current Knowledge on Graves’ Orbitopathy
por: Gontarz-Nowak, Katarzyna, et al.
Publicado: (2020)

Deep learning-based diagnosis of disease activity in patients with Graves’ orbitopathy using orbital SPECT/CT
por: Yao, Ni, et al.
Publicado: (2023)

Glycogen Synthase Kinase-3β Mediates Proinflammatory Cytokine Secretion and Adipogenesis in Orbital Fibroblasts from Patients with Graves’ Orbitopathy
por: Lee, Jihei Sara, et al.
Publicado: (2020)

Orbital Volumetry in Graves' Orbitopathy: Muscle and Fat Involvement in relation to Dysthyroid Optic Neuropathy
por: Al-Bakri, Moug, et al.
Publicado: (2014)

Graves’ disease and Graves’ orbitopathy following COVID-19
por: Lanzolla, G., et al.
Publicado: (2021)

Anti-nuclear autoantibodies in Graves’ disease and Graves’ orbitopathy
por: Lanzolla, G., et al.
Publicado: (2022)

Association of fibroblast growth factor 10 with the fibrotic and inflammatory pathogenesis of Graves’ orbitopathy
por: Jang, Sun Young, et al.
Publicado: (2021)

Independent Adipogenic and Contractile Properties of Fibroblasts in Graves’ Orbitopathy: An In Vitro Model for the Evaluation of Treatments
por: Li, He, et al.
Publicado: (2014)

Graves′ orbitopathy: Management of difficult cases
por: Wiersinga, Wilmar M.
Publicado: (2012)

Thyrotropin receptor antibodies and Graves’ orbitopathy
por: Diana, T., et al.
Publicado: (2020)

Current concepts regarding Graves’ orbitopathy
por: Bartalena, Luigi, et al.
Publicado: (2022)

Update on the surgical management of Graves’ orbitopathy
por: Baeg, Joonyoung, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_4uhfckboi8hji98d4ehqp6u3oa