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Vacuolar ATPase depletion contributes to dysregulation of endocytosis in bloodstream forms of Trypanosoma brucei

BACKGROUND: Vacuolar H(+)-ATPase (V-ATPase) is a highly conserved protein complex which hydrolyzes ATP and pumps protons to acidify vacuolar vesicles. Beyond its role in pH maintenance, the involvement of V-ATPase in endocytosis is well documented in mammals and plants but is less clear in Trypanoso...

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Detalles Bibliográficos
Autores principales: Xu, Zhi-Shen, Li, Feng-Jun, Hide, Geoff, Lun, Zhao-Rong, Lai, De-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183646/
https://www.ncbi.nlm.nih.gov/pubmed/32334612
http://dx.doi.org/10.1186/s13071-020-04068-4