Cargando…

Synergistic activation of NF-κB by TNFAIP3 (A20) reduction and UBE2L3 (UBCH7) augment that synergistically elevate lupus risk

BACKGROUND: Systemic lupus erythematosus (SLE) is an autoimmune inflammatory rheumatic disease. SLE susceptibility is affected by multiple genetic elements, environmental factors, and their interactions. We aimed in this study to statistically and functionally characterize a gene-gene interaction (e...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Taehyeung, Bae, Sang-Cheol, Kang, Changwon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183688/ https://www.ncbi.nlm.nih.gov/pubmed/32334614 http://dx.doi.org/10.1186/s13075-020-02181-4

Ejemplares similares

Synergistic recruitment of UbcH7~Ub and phosphorylated Ubl domain triggers parkin activation
por: Condos, Tara EC, et al.
Publicado: (2018)

A20 (TNFAIP3) Alleviates CVB3-Induced Myocarditis via Inhibiting NF-κB Signaling
por: Gui, Jun, et al.
Publicado: (2012)

UBE2L6/UBCH8 and ISG15 attenuate autophagy in esophageal cancer cells
por: Falvey, Chloe M., et al.
Publicado: (2017)

Let-7 miRNAs Modulate the Activation of NF-κB by Targeting TNFAIP3 and Are Involved in the Pathogenesis of Lupus Nephritis
por: Liu, Jun, et al.
Publicado: (2015)

Correction: UBE2L6/UBCH8 and ISG15 attenuate autophagy in esophageal cancer cells
por: Falvey, Chloe M., et al.
Publicado: (2020)

UBE3A and MCM6 synergistically regulate the proliferation and migration of lung adenocarcinoma cells
por: Luo, Yanyan, et al.
Publicado: (2023)

A20/TNFAIP3 heterozygosity predisposes to behavioral symptoms in a mouse model for neuropsychiatric lupus
por: Daems, C., et al.
Publicado: (2019)

A20/TNFAIP3 Discriminates Tumor Necrosis Factor (TNF)-Induced NF-κB from JNK Pathway Activation in Hepatocytes
por: Pinna, Federico, et al.
Publicado: (2017)

TNFAIP3 alleviates pain in lumbar disc herniation rats by inhibiting the NF-κB pathway
por: Xie, Zhaohui, et al.
Publicado: (2022)

Loss of NF-κB p50 function synergistically augments microglial priming in the middle-aged brain
por: Taetzsch, Thomas, et al.
Publicado: (2019)

Case Report: A Novel TNFAIP3 Mutation Causing Haploinsufficiency of A20 With a Lupus-Like Phenotype
por: Shaheen, Zachary R., et al.
Publicado: (2021)

Transcription of Tnfaip3 Is Regulated by NF-κB and p38 via C/EBPβ in Activated Macrophages
por: Lai, Ting-Yu, et al.
Publicado: (2013)

TNFAIP3(A20) genetic alterations in AIDS-related lymphomas
por: Giulino, Lisa, et al.
Publicado: (2010)

Systemic lupus erythematosus variants modulate the function of an enhancer upstream of TNFAIP3
por: Pasula, Satish, et al.
Publicado: (2022)

Novel loss-of-function mutations in TNFAIP3 gene in patients with lupus nephritis
por: Zhang, Changming, et al.
Publicado: (2022)

MicroRNA-19b-3p regulates nasopharyngeal carcinoma radiosensitivity by targeting TNFAIP3/NF-κB axis
por: Huang, Teng, et al.
Publicado: (2016)

SAG/RBX2 E3 ligase complexes with UBCH10 and UBE2S E2s to ubiquitylate β-TrCP1 via K11-linkage for degradation
por: Kuang, Peng, et al.
Publicado: (2016)

An Enhancer Element Harboring Variants Associated with Systemic Lupus Erythematosus Engages the TNFAIP3 Promoter to Influence A20 Expression
por: Wang, Shaofeng, et al.
Publicado: (2013)

HMBA Enhances Prostratin-Induced Activation of Latent HIV-1 via Suppressing the Expression of Negative Feedback Regulator A20/TNFAIP3 in NF-κB Signaling
por: Chen, Duchu, et al.
Publicado: (2016)

Association of TNFAIP3 Polymorphism with Susceptibility to Systemic Lupus Erythematosus in a Japanese Population
por: Kawasaki, Aya, et al.
Publicado: (2010)

Mutation analysis of the TNFAIP3 in A20 haploinsufficiency: A case report
por: Yan, Mei, et al.
Publicado: (2021)

YTHDF2 promotes temozolomide resistance in glioblastoma by activation of the Akt and NF‐κB signalling pathways via inhibiting EPHB3 and TNFAIP3
por: Chen, Yu, et al.
Publicado: (2022)

Segregating out UbcH10's role in tumorigenesis
por: Short, Ben
Publicado: (2010)

Co-inhibition of NF-κB and JNK is synergistic in TNF-expressing human AML
por: Volk, Andrew, et al.
Publicado: (2014)

Polymorphisms of NFκB1 and IκBα and Their Synergistic Effect on Nasopharyngeal Carcinoma Susceptibility
por: Liu, Yehua, et al.
Publicado: (2015)

Resveratrol is cytotoxic and acts synergistically with NF-κB inhibition in osteosarcoma MG-63 cells
por: Xu, Ning, et al.
Publicado: (2020)

A20 (TNFAIP3) Deletion in Epstein-Barr Virus-Associated Lymphoproliferative Disorders/Lymphomas
por: Ando, Midori, et al.
Publicado: (2013)

Deletion of the TNFAIP3/A20 gene detected by FICTION analysis in classical Hodgkin lymphoma
por: Nomoto, Junko, et al.
Publicado: (2012)

NKT sublineage specification and survival requires the ubiquitin-modifying enzyme TNFAIP3/A20
por: Drennan, Michael B., et al.
Publicado: (2016)

Juvenile onset autoinflammatory disease due to a novel mutation in TNFAIP3 (A20)
por: Sato, Shuzo, et al.
Publicado: (2018)

A critical region of A20 unveiled by missense TNFAIP3 variations that lead to autoinflammation
por: El Khouri, Elma, et al.
Publicado: (2023)

Synergistic inhibition of the APC/C by the removal of APC15 in HCT116 cells lacking UBE2C
por: Garvanska, Dimitriya H., et al.
Publicado: (2016)

An Autoimmune Disease-Associated Risk Variant in the TNFAIP3 Gene Plays a Protective Role in Brucellosis That Is Mediated by the NF-κB Signaling Pathway
por: Lou, Lixin, et al.
Publicado: (2018)

TNFAIP3 is anti-inflammatory in the retinal vasculature
por: Liu, Li, et al.
Publicado: (2022)

The Synergistic Repressive Effect of NF-κB and JNK Inhibitor on the Clonogenic Capacity of Jurkat Leukemia Cells
por: Liu, Xinli, et al.
Publicado: (2014)

Synergistic Effect of Metal Oxide Nanoparticles on Cell Viability and Activation of MAP Kinases and NFκB
por: Dávila-Grana, Ángela, et al.
Publicado: (2018)

Synergistic inhibition of lung cancer cells by EGCG and NF-κB inhibitor BAY11-7082
por: Zhang, Lingyu, et al.
Publicado: (2019)

Remission of CVB3-induced myocarditis with Astragaloside IV treatment requires A20 (TNFAIP3) up-regulation
por: Gui, Jun, et al.
Publicado: (2015)

STAT3 regulates inflammatory cytokine production downstream of TNFR1 by inducing expression of TNFAIP3/A20
por: Antonia, Ricardo J., et al.
Publicado: (2022)

Triple combination of BET plus PI3K and NF-κB inhibitors exhibit synergistic activity in adult T-cell leukemia/lymphoma
por: Daenthanasanmak, Anusara, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_bh1bk614mf042gf114subucau0