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Time-dependent simvastatin administration enhances doxorubicin toxicity in neuroblastoma

Statins have a primary indication for the reduction and management of hypercholesterolemia; however, evidence shows that statins have the ability to increase the toxicity of chemotherapeutics within cancer cells by inducing anti-proliferative, anti-metastatic, and anti-angiogenic effects. More recen...

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Detalles Bibliográficos
Autores principales: Anderson, Colin C., Khatri, Meera, Roede, James R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184108/
https://www.ncbi.nlm.nih.gov/pubmed/32368502
http://dx.doi.org/10.1016/j.toxrep.2020.03.007