Cargando…

Functional changes of the liver in the absence of growth hormone (GH) action – Proteomic and metabolomic insights from a GH receptor deficient pig model

OBJECTIVE: The liver is a central target organ of growth hormone (GH), which stimulates the synthesis of insulin-like growth factor 1 (IGF1) and affects multiple biochemical pathways. A systematic multi-omics analysis of GH effects in the liver has not been performed. GH receptor (GHR) deficiency is...

Descripción completa

Detalles Bibliográficos
Autores principales:	Riedel, Evamaria O., Hinrichs, Arne, Kemter, Elisabeth, Dahlhoff, Maik, Backman, Mattias, Rathkolb, Birgit, Prehn, Cornelia, Adamski, Jerzy, Renner, Simone, Blutke, Andreas, de Angelis, Martin Hrabĕ, Bidlingmaier, Martin, Schopohl, Jochen, Arnold, Georg J., Fröhlich, Thomas, Wolf, Eckhard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184181/ https://www.ncbi.nlm.nih.gov/pubmed/32277923 http://dx.doi.org/10.1016/j.molmet.2020.100978

Ejemplares similares

Multi-omics insights into functional alterations of the liver in insulin-deficient diabetes mellitus
por: Backman, Mattias, et al.
Publicado: (2019)

Growth hormone receptor-deficient pigs resemble the pathophysiology of human Laron syndrome and reveal altered activation of signaling cascades in the liver
por: Hinrichs, Arne, et al.
Publicado: (2018)

Mild maternal hyperglycemia in INS(C93S) transgenic pigs causes impaired glucose tolerance and metabolic alterations in neonatal offspring
por: Renner, Simone, et al.
Publicado: (2019)

Growth hormone (GH)‐transgenic insulin‐like growth factor 1 (IGF1)‐deficient mice allow dissociation of excess GH and IGF1 effects on glomerular and tubular growth
por: Blutke, Andreas, et al.
Publicado: (2016)

Laboratory investigations in the diagnosis and follow-up of GH-related disorders
por: Schilbach, Katharina, et al.
Publicado: (2019)

THU056 Reference Interval For Serum Soluble Alpha Klotho, A Sensitive Biomarker Of Growth Hormone (GH) Excess
por: de Oliveira Longo Schweizer, Júnia Ribeiro, et al.
Publicado: (2023)

A decade of experience with genetically tailored pig models for diabetes and metabolic research
por: Zettler, Silja, et al.
Publicado: (2020)

Regulation of GH and GH Signaling by Nutrients
por: Caputo, Marina, et al.
Publicado: (2021)

Maternal hyperglycemia induces alterations in hepatic amino acid, glucose and lipid metabolism of neonatal offspring: Multi-omics insights from a diabetic pig model
por: Shashikadze, Bachuki, et al.
Publicado: (2023)

Is GH Replacement for Adult GH Deficiency Safe?
por: Melmed, Shlomo
Publicado: (2022)

GH deficiency status combined with GH receptor polymorphism affects response to GH in children
por: Valsesia, Armand, et al.
Publicado: (2015)

Extensive phenotypic characterization of a new transgenic mouse reveals pleiotropic perturbations in physiology due to mesenchymal hGH minigene expression
por: Kaklamanos, Aimilios, et al.
Publicado: (2017)

Mouse Age Matters: How Age Affects the Murine Plasma Metabolome
por: Pann, Patrick, et al.
Publicado: (2020)

Diagnosis of GH Deficiency Without GH Stimulation Tests
por: Ibba, Anastasia, et al.
Publicado: (2022)

Differential Effects of Insulin-Deficient Diabetes Mellitus on Visceral vs. Subcutaneous Adipose Tissue—Multi-omics Insights From the Munich MIDY Pig Model
por: Flenkenthaler, Florian, et al.
Publicado: (2021)

GH Resistance Is a Component of Idiopathic Short Stature: Implications for rhGH Therapy
por: Savage, Martin O., et al.
Publicado: (2021)

Immobilization of Glycoside Hydrolase Families GH1, GH13, and GH70: State of the Art and Perspectives
por: Graebin, Natália G., et al.
Publicado: (2016)

GH and Senescence: A New Understanding of Adult GH Action
por: Chesnokova, Vera, et al.
Publicado: (2021)

Growth Hormone (GH) Hypersecretion and GH Receptor Resistance in Streptozotocin Diabetic Mice in Response to a GH Secretagogue
por: Johansen, Peter B., et al.
Publicado: (2003)

Functional analysis of GhCHS, GhANR and GhLAR in colored fiber formation of Gossypium hirsutum L
por: Gao, Jianfang, et al.
Publicado: (2019)

Correction to: Functional analysis of GhCHS, GhANR and GhLAR in colored fiber formation of Gossypium hirsutum L
por: Gao, Jianfang, et al.
Publicado: (2020)

Characterization of Neurospora crassa GH16, GH17, and GH72 gene families of cell wall crosslinking enzymes
por: Patel, Pavan, et al.
Publicado: (2022)

Atypical Course of a Patient With AIP-Positive Acromegaly: From GH Excess to GH Deficiency and Back to GH Excess
por: García-de-la-Torre, Keren-Sandyn, et al.
Publicado: (2023)

Metabolomics: a tool for the diagnosis of GH deficiency and for monitoring GH replacement?
por: Höybye, Charlotte, et al.
Publicado: (2014)

THU051 GH Resistance And Adipose Tissue: Multispecies Measurement Of Morphology And Transcriptome
por: Young, Jonathan A, et al.
Publicado: (2023)

GH safety workshop position paper: a critical appraisal of recombinant human GH therapy in children and adults
por: Allen, D B, et al.
Publicado: (2015)

Boosting of enzymatic softwood saccharification by fungal GH5 and GH26 endomannanases
por: von Freiesleben, Pernille, et al.
Publicado: (2018)

Unraveling the subtleties of β-(1→3)-glucan phosphorylase specificity in the GH94, GH149, and GH161 glycoside hydrolase families
por: Kuhaudomlarp, Sakonwan, et al.
Publicado: (2019)

Uromodulin Retention in Thick Ascending Limb of Henle's Loop Affects SCD1 in Neighboring Proximal Tubule: Renal Transcriptome Studies in Mouse Models of Uromodulin-Associated Kidney Disease
por: Horsch, Marion, et al.
Publicado: (2014)

The GhMAP3K62-GhMKK16-GhMPK32 kinase cascade regulates drought tolerance by activating GhEDT1-mediated ABA accumulation in cotton
por: Chen, Lin, et al.
Publicado: (2022)

Computational Studies on the Potency and Selectivity of PUGNAc Derivatives Against GH3, GH20, and GH84 β-N-acetyl-D-hexosaminidases
por: Dong, Lili, et al.
Publicado: (2019)

A long-acting GH receptor antagonist through fusion to GH binding protein
por: Wilkinson, Ian R., et al.
Publicado: (2016)

Activities of Amphioxus GH-Like Protein in Osmoregulation: Insight into Origin of Vertebrate GH Family
por: Li, Mengyang, et al.
Publicado: (2017)

What Factors Spur a Short Individual's Response to Human GH (hGH)?
por: Rogol, Alan D
Publicado: (2023)

Removing the bottlenecks of cell culture metabolomics: fast normalization procedure, correlation of metabolites to cell number, and impact of the cell harvesting method
por: Muschet, Caroline, et al.
Publicado: (2016)

Increased Secretion of Endogenous GH after Treatment with an Intranasal GH-releasing Peptide-2 Spray Does Not Promote Growth in Short Children with GH Deficiency
por: Tanaka, Toshiaki, et al.
Publicado: (2014)

Genome-wide identification of the GhARF gene family reveals that GhARF2 and GhARF18 are involved in cotton fibre cell initiation
por: Xiao, Guanghui, et al.
Publicado: (2018)

GhXB38D represses cotton fibre elongation through ubiquitination of ethylene biosynthesis enzymes GhACS4 and GhACO1
por: Song, Qingwei, et al.
Publicado: (2023)

Increased linear bone growth by GH in the absence of SOCS2 is independent of IGF‐1
por: Dobie, Ross, et al.
Publicado: (2015)

Update on GH therapy in adults
por: Boguszewski, Cesar Luiz
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_ifntcime2tsqjko9i0rpimvs8e