Single Nucleotide Polymorphisms at a Distance from Aryl Hydrocarbon Receptor (AHR) Binding Sites Influence AHR Ligand–Dependent Gene Expression

Greater than 90% of significant genome-wide association study (GWAS) single-nucleotide polymorphisms (SNPs) are in noncoding regions of the genome, but only 25.6% are known expression quantitative trait loci (eQTLs). Therefore, the function of many significant GWAS SNPs remains unclear. We have iden...

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Detalles Bibliográficos
Autores principales: Neavin, Drew R., Lee, Jeong-Heon, Liu, Duan, Ye, Zhenqing, Li, Hu, Wang, Liewei, Ordog, Tamas, Weinshilboum, Richard M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184190/
https://www.ncbi.nlm.nih.gov/pubmed/31292129
http://dx.doi.org/10.1124/dmd.119.087312

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184190/
https://www.ncbi.nlm.nih.gov/pubmed/31292129
http://dx.doi.org/10.1124/dmd.119.087312

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