Cargando…

Analyzing the impact of Mycobacterium tuberculosis infection on primary human macrophages by combined exploratory and targeted metabolomics

The pathogenic success of Mycobacterium tuberculosis (Mtb) is tightly linked to its ability to recalibrate host metabolic processes in infected host macrophages. Since changes in cellular metabolic intermediates or pathways also affect macrophage function in response to pathogens, we sought to analy...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vrieling, Frank, Kostidis, Sarantos, Spaink, Herman P., Haks, Mariëlle C., Mayboroda, Oleg A., Ottenhoff, Tom H. M., Joosten, Simone A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184630/ https://www.ncbi.nlm.nih.gov/pubmed/32341411 http://dx.doi.org/10.1038/s41598-020-62911-1

Ejemplares similares

The Effect of Hyperglycaemia on In Vitro Cytokine Production and Macrophage Infection with Mycobacterium tuberculosis
por: Lachmandas, Ekta, et al.
Publicado: (2015)

Oxidized low-density lipoprotein (oxLDL) supports Mycobacterium tuberculosis survival in macrophages by inducing lysosomal dysfunction
por: Vrieling, Frank, et al.
Publicado: (2019)

Exploratory metabolomics study of the experimental opisthorchiasis in a laboratory animal model (golden hamster, Mesocricetus auratus)
por: Kokova, Daria A., et al.
Publicado: (2017)

Human CD8(+) T-cells Recognizing Peptides from Mycobacterium tuberculosis (Mtb) Presented by HLA-E Have an Unorthodox Th2-like, Multifunctional, Mtb Inhibitory Phenotype and Represent a Novel Human T-cell Subset
por: van Meijgaarden, Krista E., et al.
Publicado: (2015)

Metabolic Reprogramming of Mammary Epithelial Cells during TGF-β-Induced Epithelial-to-Mesenchymal Transition
por: Hua, Wan, et al.
Publicado: (2021)

Functional Inhibition of Host Histone Deacetylases (HDACs) Enhances in vitro and in vivo Anti-mycobacterial Activity in Human Macrophages and in Zebrafish
por: Moreira, Jôsimar D., et al.
Publicado: (2020)

Plasma metabolomics in tuberculosis patients with and without concurrent type 2 diabetes at diagnosis and during antibiotic treatment
por: Vrieling, Frank, et al.
Publicado: (2019)

Tuberculosis causes highly conserved metabolic changes in human patients, mycobacteria-infected mice and zebrafish larvae
por: Ding, Yi, et al.
Publicado: (2020)

(1)H-NMR analysis of feces: new possibilities in the helminthes infections research
por: Kostidis, Sarantos, et al.
Publicado: (2017)

Bioorthogonal Correlative Light-Electron Microscopy of Mycobacterium tuberculosis in Macrophages Reveals the Effect of Antituberculosis Drugs on Subcellular Bacterial Distribution
por: Bakkum, Thomas, et al.
Publicado: (2020)

Metabolomic and Lipidomic Analysis of the Colorectal Adenocarcinoma Cell Line HT29 in Hypoxia and Reoxygenation
por: Barrera, Juan Carlos Alarcon, et al.
Publicado: (2023)

Biomarkers Can Identify Pulmonary Tuberculosis in HIV-infected Drug Users Months Prior to Clinical Diagnosis
por: Sloot, Rosa, et al.
Publicado: (2014)

Patients with Concurrent Tuberculosis and Diabetes Have a Pro-Atherogenic Plasma Lipid Profile
por: Vrieling, Frank, et al.
Publicado: (2018)

Identification of Probable Early-Onset Biomarkers for Tuberculosis Disease Progression
por: Sutherland, Jayne S., et al.
Publicado: (2011)

Recombinant BCG-LTAK63 Vaccine Candidate for Tuberculosis Induces an Inflammatory Profile in Human Macrophages
por: dos Santos, Carina C., et al.
Publicado: (2022)

Host‐directed therapy to combat mycobacterial infections
por: Kilinç, Gül, et al.
Publicado: (2021)

Repurposing diphenylbutylpiperidine-class antipsychotic drugs for host-directed therapy of Mycobacterium tuberculosis and Salmonella enterica infections
por: Heemskerk, M. T., et al.
Publicado: (2021)

Development of Human Cell-Based In Vitro Infection Models to Determine the Intracellular Survival of Mycobacterium avium
por: Kilinç, Gül, et al.
Publicado: (2022)

Pharmacological Poly (ADP-Ribose) Polymerase Inhibitors Decrease Mycobacterium tuberculosis Survival in Human Macrophages
por: van Doorn, Cassandra L. R., et al.
Publicado: (2021)

Tuberculosis Biomarkers: From Diagnosis to Protection
por: Goletti, Delia, et al.
Publicado: (2016)

Leptin mutation and mycobacterial infection lead non-synergistically to a similar metabolic syndrome
por: Ding, Yi, et al.
Publicado: (2022)

B-Cells and Antibodies as Contributors to Effector Immune Responses in Tuberculosis
por: Rijnink, Willemijn F., et al.
Publicado: (2021)

Identification of Major Factors Influencing ELISpot-Based Monitoring of Cellular Responses to Antigens from Mycobacterium tuberculosis
por: Smith, Steven G., et al.
Publicado: (2009)

Metabolomic and lipidomic signatures associated with activation of human cDC1 (BDCA3(+)/CD141(+)) dendritic cells
por: Basit, Farhan, et al.
Publicado: (2021)

MHC Ib molecule Qa-1 presents Mycobacterium tuberculosis peptide antigens to CD8(+) T cells and contributes to protection against infection
por: Bian, Yao, et al.
Publicado: (2017)

Metabolomic and transcriptomic profiling of adult mice and larval zebrafish leptin mutants reveal a common pattern of changes in metabolites and signaling pathways
por: Ding, Yi, et al.
Publicado: (2021)

Combination of gene expression patterns in whole blood discriminate between tuberculosis infection states
por: Mihret, Adane, et al.
Publicado: (2014)

The In Vivo Transcriptomic Blueprint of Mycobacterium tuberculosis in the Lung
por: Coppola, Mariateresa, et al.
Publicado: (2021)

Combining host-derived biomarkers with patient characteristics improves signature performance in predicting tuberculosis treatment outcomes
por: Sivakumaran, Dhanasekaran, et al.
Publicado: (2020)

Gene expression profiles classifying clinical stages of tuberculosis and monitoring treatment responses in Ethiopian HIV-negative and HIV-positive cohorts
por: Gebremicael, Gebremedhin, et al.
Publicado: (2019)

Interspecies Interactions between Clostridium difficile and Candida albicans
por: van Leeuwen, Pim T., et al.
Publicado: (2016)

IgA and IgG against Mycobacterium tuberculosis Rv2031 discriminate between pulmonary tuberculosis patients, Mycobacterium tuberculosis-infected and non-infected individuals
por: Abebe, Fekadu, et al.
Publicado: (2018)

Biomarkers to identify Mycobacterium tuberculosis infection among borderline QuantiFERON results
por: Uzorka, Jonathan W., et al.
Publicado: (2022)

Single-cell analysis reveals chemokine-mediated differential regulation of monocyte mechanics
por: Evers, Tom M.J., et al.
Publicado: (2021)

Repurposing Tamoxifen as Potential Host-Directed Therapeutic for Tuberculosis
por: Boland, Ralf, et al.
Publicado: (2022)

A Systematic Review on Novel Mycobacterium tuberculosis Antigens and Their Discriminatory Potential for the Diagnosis of Latent and Active Tuberculosis
por: Meier, Noëmi R., et al.
Publicado: (2018)

Novel transcriptional signatures for sputum-independent diagnostics of tuberculosis in children
por: Gjøen, John Espen, et al.
Publicado: (2017)

CD8(+) Regulatory T Cells, and Not CD4(+) T Cells, Dominate Suppressive Phenotype and Function after In Vitro Live Mycobacterium bovis-BCG Activation of Human Cells
por: Boer, Mardi C., et al.
Publicado: (2014)

Human CD4 T-Cells With a Naive Phenotype Produce Multiple Cytokines During Mycobacterium Tuberculosis Infection and Correlate With Active Disease
por: Orlando, Valentina, et al.
Publicado: (2018)

Host Immune Responses Differ between M. africanum- and M. tuberculosis-Infected Patients following Standard Anti-tuberculosis Treatment
por: Tientcheu, Leopold D., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_tuv4tjjc8sp8l6dd7a561cva2t