Blocking matrix metalloproteinase-mediated syndecan-4 shedding restores the endothelial glycocalyx and glomerular filtration barrier function in early diabetic kidney disease

The endothelial glycocalyx is a key component of the glomerular filtration barrier. We have shown that matrix metalloproteinase (MMP)-mediated syndecan 4 shedding is a mechanism of glomerular endothelial glycocalyx damage in vitro, resulting in increased albumin permeability. Here we sought to deter...

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Detalles Bibliográficos
Autores principales: Ramnath, Raina D., Butler, Matthew J., Newman, Georgina, Desideri, Sara, Russell, Amy, Lay, Abigail C., Neal, Chris R., Qiu, Yan, Fawaz, Sarah, Onions, Karen L., Gamez, Monica, Crompton, Michael, Michie, Chris, Finch, Natalie, Coward, Richard J., Welsh, Gavin I., Foster, Rebecca R., Satchell, Simon C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184681/
https://www.ncbi.nlm.nih.gov/pubmed/32037077
http://dx.doi.org/10.1016/j.kint.2019.09.035

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184681/
https://www.ncbi.nlm.nih.gov/pubmed/32037077
http://dx.doi.org/10.1016/j.kint.2019.09.035

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