Cargando…

Blocking matrix metalloproteinase-mediated syndecan-4 shedding restores the endothelial glycocalyx and glomerular filtration barrier function in early diabetic kidney disease

The endothelial glycocalyx is a key component of the glomerular filtration barrier. We have shown that matrix metalloproteinase (MMP)-mediated syndecan 4 shedding is a mechanism of glomerular endothelial glycocalyx damage in vitro, resulting in increased albumin permeability. Here we sought to deter...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ramnath, Raina D., Butler, Matthew J., Newman, Georgina, Desideri, Sara, Russell, Amy, Lay, Abigail C., Neal, Chris R., Qiu, Yan, Fawaz, Sarah, Onions, Karen L., Gamez, Monica, Crompton, Michael, Michie, Chris, Finch, Natalie, Coward, Richard J., Welsh, Gavin I., Foster, Rebecca R., Satchell, Simon C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184681/ https://www.ncbi.nlm.nih.gov/pubmed/32037077 http://dx.doi.org/10.1016/j.kint.2019.09.035

Ejemplares similares

Mineralocorticoid receptor antagonism in diabetes reduces albuminuria by preserving the glomerular endothelial glycocalyx
por: Crompton, Michael, et al.
Publicado: (2023)

Reactive Oxygen Species Modulate the Barrier Function of the Human Glomerular Endothelial Glycocalyx
por: Singh, Anurag, et al.
Publicado: (2013)

Endothelial glycocalyx is damaged in diabetic cardiomyopathy: angiopoietin 1 restores glycocalyx and improves diastolic function in mice
por: Qiu, Yan, et al.
Publicado: (2022)

Visualising the endothelial glycocalyx in dogs
por: Lawrence-Mills, Sara J., et al.
Publicado: (2022)

Glomerular endothelial cell fenestrations: an integral component of the glomerular filtration barrier
por: Satchell, Simon C., et al.
Publicado: (2009)

The unique structural and functional characteristics of glomerular endothelial cell fenestrations and their potential as a therapeutic target in kidney disease
por: Finch, Natalie C., et al.
Publicado: (2023)

Functional distinctions in cytosolic calcium regulation between cells of the glomerular filtration barrier
por: Foster, Rebecca Rachael, et al.
Publicado: (2010)

Shed syndecan-2 inhibits angiogenesis
por: De Rossi, Giulia, et al.
Publicado: (2014)

Regulated Shedding of Syndecan Ectodomains by Chemokines
por: Charnaux, Nathalie, et al.
Publicado: (2006)

The effects of a limited infusion rate of fluid in the early resuscitation of sepsis on glycocalyx shedding measured by plasma syndecan-1: a randomized controlled trial
por: Saoraya, Jutamas, et al.
Publicado: (2021)

Fingolimod does not prevent syndecan-4 shedding from the endothelial glycocalyx in a cultured human umbilical vein endothelial cell model of vascular injury
por: Milford, Elissa M., et al.
Publicado: (2022)

Development of an estimated glomerular filtration rate formula in cats
por: Finch, Natalie C., et al.
Publicado: (2018)

Acceleration of epithelial cell syndecan-1 shedding by anthrax hemolytic virulence factors
por: Popova, Taissia G, et al.
Publicado: (2006)

The microvascular endothelial glycocalyx: An additional piece of the puzzle in veterinary medicine
por: Lawrence-Mills, Sara J., et al.
Publicado: (2022)

A Reinterpretation of Evidence for the Endothelial Glycocalyx Filtration Structure
por: Arkill, Kenton P.
Publicado: (2021)

Syndecan‐4, a model proteoglycan to study endothelial glycocalyx mechanosensing and signal transduction
por: van den Berg, Bernard M.
Publicado: (2019)

Minimal shedding of the glycocalyx layer during abdominal hysterectomy
por: Nemme, Janis, et al.
Publicado: (2017)

Dexamethasone Suppressed LPS-Induced Matrix Metalloproteinase and Its Effect on Endothelial Glycocalyx Shedding
por: Cui, Na, et al.
Publicado: (2015)

Measuring the Concentration of Serum Syndecan-1 to Assess Vascular Endothelial Glycocalyx Injury During Hemodialysis
por: Kusuzawa, Keigo, et al.
Publicado: (2021)

Sepsis induces an early impairment of endothelial glycocalyx in glomerular capillaries
por: Vitali, L, et al.
Publicado: (2009)

Cell surface photoengineering enables modeling of glycocalyx shedding dynamics
por: Purcell, Sean C., et al.
Publicado: (2022)

Mutations in the heparan sulfate backbone elongating enzymes EXT1 and EXT2 have no major effect on endothelial glycocalyx and the glomerular filtration barrier
por: Khalil, Ramzi, et al.
Publicado: (2022)

A disintegrin and metalloproteinase 15-mediated glycocalyx shedding contributes to vascular leakage during inflammation
por: Yang, Xiaoyuan, et al.
Publicado: (2018)

Modulation of Syndecan-1 Shedding after Hemorrhagic Shock and Resuscitation
por: Haywood-Watson, Ricky J., et al.
Publicado: (2011)

The Adaptor Protein Grb2 Is Not Essential for the Establishment of the Glomerular Filtration Barrier
por: Bisson, Nicolas, et al.
Publicado: (2012)

Syndecan-1, an indicator of endothelial glycocalyx degradation, predicts outcome of patients admitted to an ICU with COVID-19
por: Zhang, Dong, et al.
Publicado: (2021)

Glomerular filtration in the aging population
por: Noronha, Irene L., et al.
Publicado: (2022)

Circulating hyaluronan as a marker of endothelial glycocalyx damage in dogs with myxomatous mitral valve disease and dogs in a hypercoagulable state
por: Lawrence-Mills, Sara J., et al.
Publicado: (2022)

Glomerular endothelial glycocalyx-derived heparan sulfate inhibits glomerular leukocyte influx and attenuates experimental glomerulonephritis
por: Maciej-Hulme, Marissa L., et al.
Publicado: (2023)

Essential role and therapeutic targeting of the glomerular endothelial glycocalyx in lupus nephritis
por: Kadoya, Hiroyuki, et al.
Publicado: (2020)

Hypervolemia increases release of atrial natriuretic peptide and shedding of the endothelial glycocalyx
por: Chappell, Daniel, et al.
Publicado: (2014)

Endothelial glycocalyx shedding and vascular permeability in severely injured trauma patients
por: Rahbar, Elaheh, et al.
Publicado: (2015)

Shed syndecan-2 enhances tumorigenic activities of colon cancer cells
por: Choi, Sojoong, et al.
Publicado: (2015)

Resolution of the three dimensional structure of components of the glomerular filtration barrier
por: Arkill, Kenton P, et al.
Publicado: (2014)

The Glomerular Filtration Barrier: Components and Crosstalk
por: Menon, Madhav C., et al.
Publicado: (2012)

The Glomerular Endothelium Restricts Albumin Filtration
por: Ballermann, Barbara J., et al.
Publicado: (2021)

Glomerular Filtration Rate Assessment in Children
por: Jančič, Sonja Golob, et al.
Publicado: (2022)

Regional distribution of N-acetyl-D-galactosamine residues in the glycocalyx of glomerular podocytes
Publicado: (1983)

Endothelial glycocalyx shedding in the acute respiratory distress syndrome after flu syndrome
por: Benatti, Maira Nilson, et al.
Publicado: (2020)

The Glycocalyx Shedding Influences Hemodynamic and Metabolic Response to Fluid Load in Septic Shock
por: Ilyina, Yana, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_m9gst3rblpa4nqsa19pljmv4em