New screening system using Twist1 promoter activity identifies dihydrorotenone as a potent drug targeting cancer-associated fibroblasts

Cancer-associated fibroblasts (CAFs) are the most abundant stromal cells in tumor microenvironments. These cells strongly support tumor progression and are considered to be potent therapeutic targets. Therefore, drugs targeting CAFs have been developed, but most of them have failed in clinical trial...

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Detalles Bibliográficos
Autores principales: Lee, Eunmyong, Yeo, So-Young, Lee, Keun-Woo, Lee, Jin A., Kim, Kyeong Kyu, Kim, Seok-Hyung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184745/
https://www.ncbi.nlm.nih.gov/pubmed/32341496
http://dx.doi.org/10.1038/s41598-020-63996-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184745/
https://www.ncbi.nlm.nih.gov/pubmed/32341496
http://dx.doi.org/10.1038/s41598-020-63996-4

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