PTEN inhibitor VO-OHpic suppresses TSC2(-)(/)(-) MEFs proliferation by excessively inhibiting autophagy via the PTEN/PRAS40 pathway

Tuberous sclerosis complex (TSC) is a relatively rare autosomal dominant disease which involves multiple organs, including the brain, kidney, lung, skin and heart. Renal angiomyolipomas (RAML) are the main causes of mortality in patients with TSC. The preferred treatment for RAML is the use of mTOR...

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Detalles Bibliográficos
Autores principales: Wang, Wenda, Wang, Xu, Guo, Hao, Cai, Yi, Zhang, Yushi, Li, Hanzhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185083/
https://www.ncbi.nlm.nih.gov/pubmed/32346419
http://dx.doi.org/10.3892/etm.2020.8629

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185083/
https://www.ncbi.nlm.nih.gov/pubmed/32346419
http://dx.doi.org/10.3892/etm.2020.8629

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