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PTEN inhibitor VO-OHpic suppresses TSC2(-)(/)(-) MEFs proliferation by excessively inhibiting autophagy via the PTEN/PRAS40 pathway
Tuberous sclerosis complex (TSC) is a relatively rare autosomal dominant disease which involves multiple organs, including the brain, kidney, lung, skin and heart. Renal angiomyolipomas (RAML) are the main causes of mortality in patients with TSC. The preferred treatment for RAML is the use of mTOR...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
D.A. Spandidos
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185083/ https://www.ncbi.nlm.nih.gov/pubmed/32346419 http://dx.doi.org/10.3892/etm.2020.8629 |