Elevated p38MAPK activity promotes neural stem cell aging

Age-progressive neural stem cell (NSC) dysfunction leads to impaired neurogenesis, cognitive decline and the onset of age-related neurodegenerative pathologies. p38MAPK signalling pathway limits stem cell activity during aging in several tissues. Its role in NSCs remains controversial. In this work,...

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Detalles Bibliográficos
Autores principales: Moreno-Cugnon, Leire, Arrizabalaga, Olatz, Llarena, Irantzu, Matheu, Ander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185101/
https://www.ncbi.nlm.nih.gov/pubmed/32243258
http://dx.doi.org/10.18632/aging.102994
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author Moreno-Cugnon, Leire
Arrizabalaga, Olatz
Llarena, Irantzu
Matheu, Ander
author_facet Moreno-Cugnon, Leire
Arrizabalaga, Olatz
Llarena, Irantzu
Matheu, Ander
author_sort Moreno-Cugnon, Leire
collection PubMed
description Age-progressive neural stem cell (NSC) dysfunction leads to impaired neurogenesis, cognitive decline and the onset of age-related neurodegenerative pathologies. p38MAPK signalling pathway limits stem cell activity during aging in several tissues. Its role in NSCs remains controversial. In this work, we show that p38MAPK activity increases in NSCs with age in the subventricular zone (SVZ) and its pharmacological inhibition is sufficient to rejuvenate their activity in vitro. These data reveal a cell-autonomous role for p38MAPK increase in decreasing NSC homeostasis with age. This information shed light in the role of p38MAPK in NSC aging.
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spelling pubmed-71851012020-05-01 Elevated p38MAPK activity promotes neural stem cell aging Moreno-Cugnon, Leire Arrizabalaga, Olatz Llarena, Irantzu Matheu, Ander Aging (Albany NY) Research Paper Age-progressive neural stem cell (NSC) dysfunction leads to impaired neurogenesis, cognitive decline and the onset of age-related neurodegenerative pathologies. p38MAPK signalling pathway limits stem cell activity during aging in several tissues. Its role in NSCs remains controversial. In this work, we show that p38MAPK activity increases in NSCs with age in the subventricular zone (SVZ) and its pharmacological inhibition is sufficient to rejuvenate their activity in vitro. These data reveal a cell-autonomous role for p38MAPK increase in decreasing NSC homeostasis with age. This information shed light in the role of p38MAPK in NSC aging. Impact Journals 2020-04-03 /pmc/articles/PMC7185101/ /pubmed/32243258 http://dx.doi.org/10.18632/aging.102994 Text en Copyright © 2020 Moreno-Cugnon et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Moreno-Cugnon, Leire
Arrizabalaga, Olatz
Llarena, Irantzu
Matheu, Ander
Elevated p38MAPK activity promotes neural stem cell aging
title Elevated p38MAPK activity promotes neural stem cell aging
title_full Elevated p38MAPK activity promotes neural stem cell aging
title_fullStr Elevated p38MAPK activity promotes neural stem cell aging
title_full_unstemmed Elevated p38MAPK activity promotes neural stem cell aging
title_short Elevated p38MAPK activity promotes neural stem cell aging
title_sort elevated p38mapk activity promotes neural stem cell aging
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185101/
https://www.ncbi.nlm.nih.gov/pubmed/32243258
http://dx.doi.org/10.18632/aging.102994
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AT matheuander elevatedp38mapkactivitypromotesneuralstemcellaging

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