Cargando…

Elevated p38MAPK activity promotes neural stem cell aging

Age-progressive neural stem cell (NSC) dysfunction leads to impaired neurogenesis, cognitive decline and the onset of age-related neurodegenerative pathologies. p38MAPK signalling pathway limits stem cell activity during aging in several tissues. Its role in NSCs remains controversial. In this work,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Moreno-Cugnon, Leire, Arrizabalaga, Olatz, Llarena, Irantzu, Matheu, Ander
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals 2020
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185101/ https://www.ncbi.nlm.nih.gov/pubmed/32243258 http://dx.doi.org/10.18632/aging.102994

Ejemplares similares

Neuronal p38α mediates age‐associated neural stem cell exhaustion and cognitive decline
por: Moreno‐Cugnon, Leire, et al.
Publicado: (2019)

Increased Arf/p53 activity in stem cells, aging and cancer
por: Carrasco‐Garcia, Estefania, et al.
Publicado: (2017)

In vitro P38MAPK inhibition in aged astrocytes decreases reactive astrocytes, inflammation and increases nutritive capacity after oxygen-glucose deprivation
por: Revuelta, Miren, et al.
Publicado: (2021)

SOX2 haploinsufficiency promotes impaired vision at advanced age
por: Moreno-Cugnon, Leire, et al.
Publicado: (2018)

Increased gene dosage of Ink4/Arf and p53 delays age-associated central nervous system functional decline
por: Carrasco-Garcia, Estefania, et al.
Publicado: (2015)

mTOR inhibition decreases SOX2-SOX9 mediated glioma stem cell activity and temozolomide resistance
por: Garros-Regulez, Laura, et al.
Publicado: (2016)

CD8(+) T cells are increased in the subventricular zone with physiological and pathological aging
por: Moreno‐Valladares, Manuel, et al.
Publicado: (2020)

CD8(+) T cells are present at low levels in the white matter with physiological and pathological aging
por: Moreno-Valladares, Manuel, et al.
Publicado: (2020)

Targeting SOX2 as a Therapeutic Strategy in Glioblastoma
por: Garros-Regulez, Laura, et al.
Publicado: (2016)

Expression of cellular senescence and neural stem cell markers in a case of advanced retinal fibrosis
por: Moreno‐Valladares, Manuel, et al.
Publicado: (2019)

Autophagy in stem cell aging
por: Revuelta, Miren, et al.
Publicado: (2017)

Liquid Biopsy in Glioblastoma: Opportunities, Applications and Challenges
por: Saenz-Antoñanzas, Ander, et al.
Publicado: (2019)

p38 MAPK in MDS
por: Gañán‐Gómez, Irene, et al.
Publicado: (2015)

High expression of MKP1/DUSP1 counteracts glioma stem cell activity and mediates HDAC inhibitor response
por: Arrizabalaga, Olatz, et al.
Publicado: (2017)

WIP1 promotes cancer stem cell properties by inhibiting p38 MAPK in NSCLC
por: Deng, Kaiyuan, et al.
Publicado: (2020)

KRT5(+)/p63(+) Stem Cells Undergo Senescence in the Human Lung with Pathological Aging
por: Moreno-Valladares, Manuel, et al.
Publicado: (2023)

FGF9 promotes mouse spermatogonial stem cell proliferation mediated by p38 MAPK signalling
por: Yang, Fan, et al.
Publicado: (2020)

Dehydrocorydaline promotes myogenic differentiation via p38 MAPK activation
por: Yoo, Miran, et al.
Publicado: (2016)

New Insights into the p38γ and p38δ MAPK Pathways
por: Risco, Ana, et al.
Publicado: (2012)

p38γ and p38δ Mitogen Activated Protein Kinases (MAPKs), New Stars in the MAPK Galaxy
por: Escós, Alejandra, et al.
Publicado: (2016)

MAPK p38alpha Kinase Influences Haematopoiesis in Embryonic Stem Cells
por: Štefková, Kateřina, et al.
Publicado: (2019)

Involvement of p38 MAPK in Leydig cell aging and age-related decline in testosterone
por: Luo, Dandan, et al.
Publicado: (2023)

P38 MAPK Signaling in the Retina: Effects of Aging and Age-Related Macular Degeneration
por: Muraleva, Natalia A., et al.
Publicado: (2023)

The role of p38b MAPK in age-related modulation of intestinal stem cell proliferation and differentiation in Drosophila
por: Park, Joung-Sun, et al.
Publicado: (2009)

p38 MAPK Signaling in Osteoblast Differentiation
por: Rodríguez-Carballo, Eddie, et al.
Publicado: (2016)

p38 MAPK in cardioprotection – are we there yet?
por: Martin, E D, et al.
Publicado: (2015)

P38 MAPK and Radiotherapy: Foes or Friends?
por: García-Flores, Natalia, et al.
Publicado: (2023)

Gut stem cell aging is driven by mTORC1 via a p38 MAPK-p53 pathway
por: He, Dan, et al.
Publicado: (2020)

Elevated COX-2 Expression Promotes Angiogenesis Through EGFR/p38-MAPK/Sp1-Dependent Signalling in Pancreatic Cancer
por: Hu, Hai, et al.
Publicado: (2017)

Age-dependent regulation of antioxidant genes by p38α MAPK in the liver
por: Pérez, Salvador, et al.
Publicado: (2018)

Zebularine Promotes Hepatic Differentiation of Rabbit Bone Marrow Mesenchymal Stem Cells by Interfering with p38 MAPK Signaling
por: Luo, Yong-Heng, et al.
Publicado: (2018)

Caspases and p38 MAPK Regulate Endothelial Cell Adhesiveness for Mesenchymal Stem Cells
por: Potapova, Irina A., et al.
Publicado: (2013)

Hypermethylation of MAPK13 Promoter in Oesophageal Squamous Cell Carcinoma Is Associated with Loss of p38δ MAPK Expression
por: O′Callaghan, Carol, et al.
Publicado: (2015)

TRIM59 Promotes Retinoblastoma Progression by Activating the p38–MAPK Signaling Pathway
por: Wu, Chao, et al.
Publicado: (2020)

SERPINB4 Promotes Keratinocyte Inflammation via p38MAPK Signaling Pathway
por: Zhang, Yanan, et al.
Publicado: (2023)

p38 MAPK, microglial signaling, and neuropathic pain
por: Ji, Ru-Rong, et al.
Publicado: (2007)

The Role of p38 MAPK in the Development of Diabetic Cardiomyopathy
por: Wang, Shudong, et al.
Publicado: (2016)

Cancer suppression by systemic inactivation of p38MAPK
por: Brichkina, Anna, et al.
Publicado: (2017)

Involvement of p38 MAPK in Synaptic Function and Dysfunction
por: Falcicchia, Chiara, et al.
Publicado: (2020)

Crosstalk between p38 MAPK and GR Signaling
por: Zeyen, Lisa, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_fbr7cvgjrmd8o1itpnj7rmio3g