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Spermidine and spermine delay brain aging by inducing autophagy in SAMP8 mice

The natural polyamine spermidine and spermine have been reported to ameliorate aging and aging-induced dementia. However, the mechanism is still confused. An aging model, the senescence accelerated mouse-8 (SAMP8), was used in this study. Novel object recognition and the open field test results show...

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Autores principales: Xu, Ting-Ting, Li, Han, Dai, Zhao, Lau, George K., Li, Ben-Yue, Zhu, Wen-Li, Liu, Xiao-Qi, Liu, Hao-Fei, Cai, Wei-Wu, Huang, Shui-Qing, Wang, Qi, Zhang, Shi-Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185103/
https://www.ncbi.nlm.nih.gov/pubmed/32268299
http://dx.doi.org/10.18632/aging.103035
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author Xu, Ting-Ting
Li, Han
Dai, Zhao
Lau, George K.
Li, Ben-Yue
Zhu, Wen-Li
Liu, Xiao-Qi
Liu, Hao-Fei
Cai, Wei-Wu
Huang, Shui-Qing
Wang, Qi
Zhang, Shi-Jie
author_facet Xu, Ting-Ting
Li, Han
Dai, Zhao
Lau, George K.
Li, Ben-Yue
Zhu, Wen-Li
Liu, Xiao-Qi
Liu, Hao-Fei
Cai, Wei-Wu
Huang, Shui-Qing
Wang, Qi
Zhang, Shi-Jie
author_sort Xu, Ting-Ting
collection PubMed
description The natural polyamine spermidine and spermine have been reported to ameliorate aging and aging-induced dementia. However, the mechanism is still confused. An aging model, the senescence accelerated mouse-8 (SAMP8), was used in this study. Novel object recognition and the open field test results showed that oral administration of spermidine, spermine and rapamycin increased discrimination index, modified number, inner squares distance and times. Spermidine and spermine increased the activity of SOD, and decreased the level of MDA in the aging brain. Spermidine and spermine phosphorylate AMPK and regulate autophagy proteins (LC3, Beclin 1 and p62). Spermidine and spermine balanced mitochondrial and maintain energy for neuron, with the regulation of MFN1, MFN2, DRP1, COX IV and ATP. In addition, western blot results (Bcl-2, Bax and Caspase-3, NLRP3, IL-18, IL-1β) showed that spermidine and spermine prevented apoptosis and inflammation, and elevate the expression of neurotrophic factors, including NGF, PSD95and PSD93 and BDNF in neurons of SAMP8 mice. These results indicated that the effect of spermidine and spermine on anti-aging is related with improving autophagy and mitochondrial function.
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spelling pubmed-71851032020-05-01 Spermidine and spermine delay brain aging by inducing autophagy in SAMP8 mice Xu, Ting-Ting Li, Han Dai, Zhao Lau, George K. Li, Ben-Yue Zhu, Wen-Li Liu, Xiao-Qi Liu, Hao-Fei Cai, Wei-Wu Huang, Shui-Qing Wang, Qi Zhang, Shi-Jie Aging (Albany NY) Research Paper The natural polyamine spermidine and spermine have been reported to ameliorate aging and aging-induced dementia. However, the mechanism is still confused. An aging model, the senescence accelerated mouse-8 (SAMP8), was used in this study. Novel object recognition and the open field test results showed that oral administration of spermidine, spermine and rapamycin increased discrimination index, modified number, inner squares distance and times. Spermidine and spermine increased the activity of SOD, and decreased the level of MDA in the aging brain. Spermidine and spermine phosphorylate AMPK and regulate autophagy proteins (LC3, Beclin 1 and p62). Spermidine and spermine balanced mitochondrial and maintain energy for neuron, with the regulation of MFN1, MFN2, DRP1, COX IV and ATP. In addition, western blot results (Bcl-2, Bax and Caspase-3, NLRP3, IL-18, IL-1β) showed that spermidine and spermine prevented apoptosis and inflammation, and elevate the expression of neurotrophic factors, including NGF, PSD95and PSD93 and BDNF in neurons of SAMP8 mice. These results indicated that the effect of spermidine and spermine on anti-aging is related with improving autophagy and mitochondrial function. Impact Journals 2020-04-08 /pmc/articles/PMC7185103/ /pubmed/32268299 http://dx.doi.org/10.18632/aging.103035 Text en Copyright © 2020 Xu et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Xu, Ting-Ting
Li, Han
Dai, Zhao
Lau, George K.
Li, Ben-Yue
Zhu, Wen-Li
Liu, Xiao-Qi
Liu, Hao-Fei
Cai, Wei-Wu
Huang, Shui-Qing
Wang, Qi
Zhang, Shi-Jie
Spermidine and spermine delay brain aging by inducing autophagy in SAMP8 mice
title Spermidine and spermine delay brain aging by inducing autophagy in SAMP8 mice
title_full Spermidine and spermine delay brain aging by inducing autophagy in SAMP8 mice
title_fullStr Spermidine and spermine delay brain aging by inducing autophagy in SAMP8 mice
title_full_unstemmed Spermidine and spermine delay brain aging by inducing autophagy in SAMP8 mice
title_short Spermidine and spermine delay brain aging by inducing autophagy in SAMP8 mice
title_sort spermidine and spermine delay brain aging by inducing autophagy in samp8 mice
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185103/
https://www.ncbi.nlm.nih.gov/pubmed/32268299
http://dx.doi.org/10.18632/aging.103035
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