Down-regulation of AMPK signaling pathway rescues hearing loss in TFB1 transgenic mice and delays age-related hearing loss

AMP-activated protein kinase (AMPK) integrates the regulation of cell growth and metabolism. AMPK activation occurs in response to cellular energy decline and mitochondrial dysfunction triggered by reactive oxygen species (ROS). In aged Tg-mtTFB1 mice, a mitochondrial deafness mouse model, hearing l...

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Detalles Bibliográficos
Autores principales: Zhao, Jingjing, Li, Gen, Zhao, Xuan, Lin, Xin, Gao, Yunge, Raimundo, Nuno, Li, Geng-Lin, Shang, Wei, Wu, Hao, Song, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2020
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185105/
https://www.ncbi.nlm.nih.gov/pubmed/32240104
http://dx.doi.org/10.18632/aging.102977

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185105/
https://www.ncbi.nlm.nih.gov/pubmed/32240104
http://dx.doi.org/10.18632/aging.102977

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