Myotonic Dystrophy type 1 cells display impaired metabolism and mitochondrial dysfunction that are reversed by metformin

Myotonic dystrophy type 1 (DM1; MIM #160900) is an autosomal dominant disorder, clinically characterized by progressive muscular weakness and multisystem degeneration. The broad phenotypes observed in patients with DM1 resemble the appearance of a multisystem accelerated aging process. However, the...

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Detalles Bibliográficos
Autores principales: García-Puga, Mikel, Saenz-Antoñanzas, Ander, Fernández-Torrón, Roberto, de Munain, Adolfo Lopez, Matheu, Ander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185118/
https://www.ncbi.nlm.nih.gov/pubmed/32310829
http://dx.doi.org/10.18632/aging.103022

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185118/
https://www.ncbi.nlm.nih.gov/pubmed/32310829
http://dx.doi.org/10.18632/aging.103022

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