Supraphysiological protection from replication stress does not extend mammalian lifespan

Replication Stress (RS) is a type of DNA damage generated at the replication fork, characterized by single-stranded DNA (ssDNA) accumulation, and which can be caused by a variety of factors. Previous studies have reported elevated RS levels in aged cells. In addition, mouse models with a deficient R...

Descripción completa

Detalles Bibliográficos
Autores principales: Albers, Eliene, Avram, Alexandra, Sbroggio, Mauro, Fernandez-Capetillo, Oscar, Lopez-Contreras, Andres J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2020
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185120/
https://www.ncbi.nlm.nih.gov/pubmed/32253367
http://dx.doi.org/10.18632/aging.103039

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185120/
https://www.ncbi.nlm.nih.gov/pubmed/32253367
http://dx.doi.org/10.18632/aging.103039

Ejemplares similares