Cargando…

Supraphysiological protection from replication stress does not extend mammalian lifespan

Replication Stress (RS) is a type of DNA damage generated at the replication fork, characterized by single-stranded DNA (ssDNA) accumulation, and which can be caused by a variety of factors. Previous studies have reported elevated RS levels in aged cells. In addition, mouse models with a deficient R...

Descripción completa

Detalles Bibliográficos
Autores principales:	Albers, Eliene, Avram, Alexandra, Sbroggio, Mauro, Fernandez-Capetillo, Oscar, Lopez-Contreras, Andres J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals 2020
Materias:	Priority Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185120/ https://www.ncbi.nlm.nih.gov/pubmed/32253367 http://dx.doi.org/10.18632/aging.103039

Ejemplares similares

Loss of PICH Results in Chromosomal Instability, p53 Activation, and Embryonic Lethality
por: Albers, Eliene, et al.
Publicado: (2018)

Increased uncoupling protein (UCP) activity in Drosophila insulin-producing neurons attenuates insulin signaling and extends lifespan
por: Fridell, Yih-Woei C., et al.
Publicado: (2009)

Mammalian models of extended healthy lifespan
por: Selman, Colin, et al.
Publicado: (2011)

Efficacy of ATR inhibitors as single agents in Ewing sarcoma
por: Nieto-Soler, Maria, et al.
Publicado: (2016)

The mitochondrial derived peptide humanin is a regulator of lifespan and healthspan
por: Yen, Kelvin, et al.
Publicado: (2020)

Buffering the pH of the culture medium does not extend yeast replicative lifespan
por: Wasko, Brian M, et al.
Publicado: (2013)

Supraphysiological Oxygen Levels in Mammalian Cell Culture: Current State and Future Perspectives
por: Alva, Ricardo, et al.
Publicado: (2022)

Comparison of SARS-CoV-2 RT-PCR on a high-throughput molecular diagnostic platform and the cobas SARS-CoV-2 test for the diagnostic of COVID-19 on various clinical samples
por: Opota, Onya, et al.
Publicado: (2020)

Green tea catechins EGCG and ECG enhance the fitness and lifespan of Caenorhabditis elegans by complex I inhibition
por: Tian, Jing, et al.
Publicado: (2021)

Pan-mammalian analysis of molecular constraints underlying extended lifespan
por: Kowalczyk, Amanda, et al.
Publicado: (2020)

ATR expands embryonic stem cell fate potential in response to replication stress
por: Atashpaz, Sina, et al.
Publicado: (2020)

Inhibition of mammalian S6 kinase by resveratrol suppresses autophagy
por: Armour, Sean M., et al.
Publicado: (2009)

Maternal supraphysiological hypercholesterolemia associates with endothelial dysfunction of the placental microvasculature
por: Fuenzalida, Bárbara, et al.
Publicado: (2018)

Long-term treatment with chloroquine increases lifespan in middle-aged male mice possibly via autophagy modulation, proteasome inhibition and glycogen metabolism
por: Doeppner, Thorsten R., et al.
Publicado: (2022)

Elevated Proteasome Capacity Extends Replicative Lifespan in Saccharomyces cerevisiae
por: Kruegel, Undine, et al.
Publicado: (2011)

Striatal DAT availability does not change after supraphysiological glucose loading dose in humans
por: Pak, Kyoungjune, et al.
Publicado: (2021)

Beta-guanidinopropionic acid does not extend Drosophila lifespan
por: Dorigatti, Jonathan D., et al.
Publicado: (2021)

An extra allele of Chk1 limits oncogene-induced replicative stress and promotes transformation
por: López-Contreras, Andres J., et al.
Publicado: (2012)

Synergistic and targeted therapy with a procaspase-3 activator and temozolomide extends survival in glioma rodent models and is feasible for the treatment of canine malignant glioma patients
por: Joshi, Avadhut D., et al.
Publicado: (2017)

The overexpression of major antioxidant enzymes does not extend the lifespan of mice
por: Pérez, Viviana I, et al.
Publicado: (2009)

Metabolic modeling predicts perturbations extending lifespan in yeast and counteracting aging in mammalian muscle
por: Yizhak, Keren, et al.
Publicado: (2012)

Replication of Extended Lifespan Phenotype in Mice with Deletion of Insulin Receptor Substrate 1
por: Selman, Colin, et al.
Publicado: (2011)

Hypophosphatemia Due to Increased Effector Cell Metabolic Activity Is Associated with Neurotoxicity Symptoms in CD19-Targeted CAR T-cell Therapy
por: Tang, Jack Pengfei, et al.
Publicado: (2022)

Hexosamine pathway activation improves memory but does not extend lifespan in mice
por: Allmeroth, Kira, et al.
Publicado: (2022)

Loss of Mitochondrial Membrane Potential Triggers the Retrograde Response Extending Yeast Replicative Lifespan
por: Miceli, Michael V., et al.
Publicado: (2012)

Malate and Fumarate Extend Lifespan in Caenorhabditis elegans
por: Edwards, Clare B., et al.
Publicado: (2013)

Role for Tetrahydrobiopterin in the Fetoplacental Endothelial Dysfunction in Maternal Supraphysiological Hypercholesterolemia
por: Leiva, Andrea, et al.
Publicado: (2016)

Supraphysiological Testosterone Therapy as Treatment for Castration-Resistant Prostate Cancer
por: Lam, Hung-Ming, et al.
Publicado: (2018)

Supraphysiological levels of GDF11 induce striated muscle atrophy
por: Hammers, David W, et al.
Publicado: (2017)

Cholesterol uptake and efflux are impaired in human trophoblast cells from pregnancies with maternal supraphysiological hypercholesterolemia
por: Fuenzalida, Bárbara, et al.
Publicado: (2020)

Loss of PACS-2 delays regeneration in DSS-induced colitis but does not affect the Apc(Min) model of colorectal cancer
por: Dombernowsky, Sarah L., et al.
Publicado: (2017)

Frame-shift mediated reduction of gain-of-function p53 R273H and deletion of the R273H C-terminus in breast cancer cells result in replication-stress sensitivity
por: Ellison, Viola, et al.
Publicado: (2021)

CD3xPDL1 bi-specific T cell engager (BiTE) simultaneously activates T cells and NKT cells, kills PDL1(+) tumor cells, and extends the survival of tumor-bearing humanized mice
por: Horn, Lucas A., et al.
Publicado: (2017)

Rejuvant®, a potential life-extending compound formulation with alpha-ketoglutarate and vitamins, conferred an average 8 year reduction in biological aging, after an average of 7 months of use, in the TruAge DNA methylation test
por: Demidenko, Oleksandr, et al.
Publicado: (2021)

Mitochondrial metabolites extend lifespan
por: Mishur, Robert J., et al.
Publicado: (2016)

Pharmacologic Means of Extending Lifespan
por: Lamming, Dudley W., et al.
Publicado: (2012)

The replicative lifespan‐extending deletion of SGF73 results in altered ribosomal gene expression in yeast
por: Mason, Amanda G., et al.
Publicado: (2017)

Evolution of Natural Lifespan Variation and Molecular Strategies of Extended Lifespan
por: Kaya, Alaattin
Publicado: (2021)

Adrenal Incidentalomas with Supraphysiologic Response to ACTH Stimulus: A Case Report
por: Antonopoulou, Marianna, et al.
Publicado: (2012)

Effects of Supraphysiological Doses of Sex Steroids on Wheel Running Activity in Mice
por: Bowen, Robert S, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_fqko758gt8607r79gl5nh8ntjc