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Ube2s-stabilized β-catenin protects against myocardial ischemia/reperfusion injury by activating HIF-1α signaling

The activation of hypoxia-inducible factor (HIF) is an important event for mediating the adaptive response to myocardial ischemia/reperfusion (MI/R) injury. The ubiquitin-conjugating enzyme E2S (Ube2s) catalyzes ubiquitin conjugation to target proteins. Here, we report the positive regulation of HIF...

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Detalles Bibliográficos
Autores principales: Chen, Xi, Wang, Chiyao, Yang, Pei, Shi, Lei, Wang, Haiyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185123/
https://www.ncbi.nlm.nih.gov/pubmed/32250966
http://dx.doi.org/10.18632/aging.102960