Targeting ubiquitin protein ligase E3 component N-recognin 5 in cancer cells induces a CD8+ T cell mediated immune response

UBR5 is a nuclear phosphoprotein of obscure functions. Clinical analyses reveal that UBR5 amplifications and overexpression occur in over 20% cases of human breast cancers. Breast cancer patients carrying UBR5 genetic lesions with overexpression have significantly reduced survival. Experimental work...

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Detalles Bibliográficos
Autores principales: Song, Mei, Wang, Chao, Wang, Huan, Zhang, Tuo, Li, Jiuqi, Benezra, Robert, Chouchane, Lotfi, Sun, Yin-Hao, Cui, Xin-Gang, Ma, Xiaojing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185213/
https://www.ncbi.nlm.nih.gov/pubmed/32363114
http://dx.doi.org/10.1080/2162402X.2020.1746148

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185213/
https://www.ncbi.nlm.nih.gov/pubmed/32363114
http://dx.doi.org/10.1080/2162402X.2020.1746148

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