Targeting the viral Achilles’ heel: recognition of 5′-triphosphate RNA in innate anti-viral defence

Some RNA virus genomes bear 5′-triphosphates, which can be recognized in the cytoplasm of infected cells by host proteins that mediate anti-viral immunity. Both the innate sensor RIG-I and the interferon-induced IFIT proteins bind to 5′-triphosphate viral RNAs. RIG-I signals for induction of interfe...

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Detalles Bibliográficos
Autores principales: Rehwinkel, Jan, Reis e Sousa, Caetano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185528/
https://www.ncbi.nlm.nih.gov/pubmed/23707340
http://dx.doi.org/10.1016/j.mib.2013.04.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185528/
https://www.ncbi.nlm.nih.gov/pubmed/23707340
http://dx.doi.org/10.1016/j.mib.2013.04.009

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