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Targeting the viral Achilles’ heel: recognition of 5′-triphosphate RNA in innate anti-viral defence
Some RNA virus genomes bear 5′-triphosphates, which can be recognized in the cytoplasm of infected cells by host proteins that mediate anti-viral immunity. Both the innate sensor RIG-I and the interferon-induced IFIT proteins bind to 5′-triphosphate viral RNAs. RIG-I signals for induction of interfe...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier Ltd.
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185528/ https://www.ncbi.nlm.nih.gov/pubmed/23707340 http://dx.doi.org/10.1016/j.mib.2013.04.009 |