The Eukaryotic Translation Initiation Factor 4E (eIF4E) as a Therapeutic Target for Cancer

Cancer cells depend on cap-dependent translation more than normal tissue. This explains the emergence of proteins involved in the cap-dependent translation as targets for potential anticancer drugs. Cap-dependent translation starts when eIF4E binds to mRNA cap domain. This review will present eIF4E&...

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Autores principales: Karaki, Sara, Andrieu, Claudia, Ziouziou, Hajer, Rocchi, Palma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185574/
https://www.ncbi.nlm.nih.gov/pubmed/26572974
http://dx.doi.org/10.1016/bs.apcsb.2015.09.001
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author Karaki, Sara
Andrieu, Claudia
Ziouziou, Hajer
Rocchi, Palma
author_facet Karaki, Sara
Andrieu, Claudia
Ziouziou, Hajer
Rocchi, Palma
author_sort Karaki, Sara
collection PubMed
description Cancer cells depend on cap-dependent translation more than normal tissue. This explains the emergence of proteins involved in the cap-dependent translation as targets for potential anticancer drugs. Cap-dependent translation starts when eIF4E binds to mRNA cap domain. This review will present eIF4E's structure and functions. It will also expose the use of eIF4E as a therapeutic target in cancer.
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spelling pubmed-71855742020-04-28 The Eukaryotic Translation Initiation Factor 4E (eIF4E) as a Therapeutic Target for Cancer Karaki, Sara Andrieu, Claudia Ziouziou, Hajer Rocchi, Palma Adv Protein Chem Struct Biol Article Cancer cells depend on cap-dependent translation more than normal tissue. This explains the emergence of proteins involved in the cap-dependent translation as targets for potential anticancer drugs. Cap-dependent translation starts when eIF4E binds to mRNA cap domain. This review will present eIF4E's structure and functions. It will also expose the use of eIF4E as a therapeutic target in cancer. Elsevier Inc. 2015 2015-10-23 /pmc/articles/PMC7185574/ /pubmed/26572974 http://dx.doi.org/10.1016/bs.apcsb.2015.09.001 Text en Copyright © 2015 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Karaki, Sara
Andrieu, Claudia
Ziouziou, Hajer
Rocchi, Palma
The Eukaryotic Translation Initiation Factor 4E (eIF4E) as a Therapeutic Target for Cancer
title The Eukaryotic Translation Initiation Factor 4E (eIF4E) as a Therapeutic Target for Cancer
title_full The Eukaryotic Translation Initiation Factor 4E (eIF4E) as a Therapeutic Target for Cancer
title_fullStr The Eukaryotic Translation Initiation Factor 4E (eIF4E) as a Therapeutic Target for Cancer
title_full_unstemmed The Eukaryotic Translation Initiation Factor 4E (eIF4E) as a Therapeutic Target for Cancer
title_short The Eukaryotic Translation Initiation Factor 4E (eIF4E) as a Therapeutic Target for Cancer
title_sort eukaryotic translation initiation factor 4e (eif4e) as a therapeutic target for cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185574/
https://www.ncbi.nlm.nih.gov/pubmed/26572974
http://dx.doi.org/10.1016/bs.apcsb.2015.09.001
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