Cofactor and glycosylation preferences for in vitro prion conversion are predominantly determined by strain conformation

Prion diseases are caused by the misfolding of a host-encoded glycoprotein, PrP(C), into a pathogenic conformer, PrP(Sc). Infectious prions can exist as different strains, composed of unique conformations of PrP(Sc) that generate strain-specific biological traits, including distinctive patterns of P...

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Detalles Bibliográficos
Autores principales: Burke, Cassandra M., Walsh, Daniel J., Mark, Kenneth M. K., Deleault, Nathan R., Nishina, Koren A., Agrimi, Umberto, Di Bari, Michele A., Supattapone, Surachai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185723/
https://www.ncbi.nlm.nih.gov/pubmed/32294141
http://dx.doi.org/10.1371/journal.ppat.1008495

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185723/
https://www.ncbi.nlm.nih.gov/pubmed/32294141
http://dx.doi.org/10.1371/journal.ppat.1008495

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