Cargando…
Cofactor and glycosylation preferences for in vitro prion conversion are predominantly determined by strain conformation
Prion diseases are caused by the misfolding of a host-encoded glycoprotein, PrP(C), into a pathogenic conformer, PrP(Sc). Infectious prions can exist as different strains, composed of unique conformations of PrP(Sc) that generate strain-specific biological traits, including distinctive patterns of P...
| Autores principales: | , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2020
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185723/ https://www.ncbi.nlm.nih.gov/pubmed/32294141 http://dx.doi.org/10.1371/journal.ppat.1008495 |