Cargando…

A novel semisynthesized small molecule icaritin reduces incidence of steroid-associated osteonecrosis with inhibition of both thrombosis and lipid-deposition in a dose-dependent manner

BACKGROUND: Intravascular-thrombosis and extravascular-lipid-deposition are the two key pathogenic events considered to interrupt intraosseous blood supply during steroid-associated osteonecrosis (ON) development. However, there are no reported candidate agents capable of simultaneously targeting th...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Ge, Qin, Ling, Sheng, Hui, Wang, Xin-Luan, Wang, Yi-Xiang, Yeung, David Ka-Wai, Griffith, James F., Yao, Xin-Sheng, Xie, Xin-Hui, Li, Zi-Rong, Lee, Kwong-Man, Leung, Kwok-Sui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185883/
https://www.ncbi.nlm.nih.gov/pubmed/19015051
http://dx.doi.org/10.1016/j.bone.2008.10.035