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The Rho-guanine nucleotide exchange factor Solo decelerates collective cell migration by modulating the Rho-ROCK pathway and keratin networks
Collective cell migration plays crucial roles in tissue remodeling, wound healing, and cancer cell invasion. However, its underlying mechanism remains unknown. Previously, we showed that the RhoA-targeting guanine nucleotide exchange factor Solo (ARHGEF40) is required for tensile force–induced RhoA...
Autores principales: | Isozaki, Yusuke, Sakai, Kouki, Kohiro, Kenta, Kagoshima, Katsuhiko, Iwamura, Yuma, Sato, Hironori, Rindner, Daniel, Fujiwara, Sachiko, Yamashita, Kazunari, Mizuno, Kensaku, Ohashi, Kazumasa |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The American Society for Cell Biology
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185966/ https://www.ncbi.nlm.nih.gov/pubmed/32049581 http://dx.doi.org/10.1091/mbc.E19-07-0357 |
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