Deep evolutionary analysis reveals the design principles of fold A glycosyltransferases

Glycosyltransferases (GTs) are prevalent across the tree of life and regulate nearly all aspects of cellular functions. The evolutionary basis for their complex and diverse modes of catalytic functions remain enigmatic. Here, based on deep mining of over half million GT-A fold sequences, we define a...

Descripción completa

Detalles Bibliográficos
Autores principales: Taujale, Rahil, Venkat, Aarya, Huang, Liang-Chin, Zhou, Zhongliang, Yeung, Wayland, Rasheed, Khaled M, Li, Sheng, Edison, Arthur S, Moremen, Kelley W, Kannan, Natarajan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Computational and Systems Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185993/
https://www.ncbi.nlm.nih.gov/pubmed/32234211
http://dx.doi.org/10.7554/eLife.54532

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185993/
https://www.ncbi.nlm.nih.gov/pubmed/32234211
http://dx.doi.org/10.7554/eLife.54532

Ejemplares similares